3,4-二氢-1H-喹唑啉-2-酮合成路线 （共 9 条）
反应条件
N-methyl-pyrrolidine; selenium in tetrahydrofuran
T=15°C; P=735.5 Torr; 10 h; 1.) THF, 1 at, 15 deg C, 1 h; 2.) 5 h;
参考文献
Yoshida, Tohru; Kambe, Nobuaki; Murai, Shinji; Sonoda, Noboru
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, p. 1793 - 1800
反应条件
nickel in ethanol
2 h; Heating;
参考文献
Yoshida, Tohru; Kambe, Nobuaki; Ogawa, Akiya; Sonoda, Noboru
Phosphorus and Sulfur and the Related Elements, 1988 , vol. 38, p. 137 - 148
反应条件
PhTMG; diphenyl phosphoryl azide in acetonitrile
T=-40 - 25°C;
参考文献
Paz, Jairo; Perez-Balado, Carlos; Iglesias, Beatriz; Munoz, Luis
Journal of Organic Chemistry, 2010 , vol. 75, # 9 p. 3037 - 3046
反应条件
zirconium tetra-t-butoxide
T=140°C; 0.25 h; microwave irradiation;
参考文献
Han, Chong; Porco Jr., John A.
Organic Letters, 2007 , vol. 9, # 8 p. 1517 - 1520
反应条件
in methanol
T=60°C; 24 h;
参考文献
Leung, Man-Kit; Lai, Jun-Liang; Lau, King-Hang; Yu, Hsiao-Hua; Hsiao, Hsiang-Ju
Journal of Organic Chemistry, 1996 , vol. 61, # 12 p. 4175 - 4179
反应条件
1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.25 h / 0 - 20 °C
3: trifluoroacetic acid / dichloromethane
4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 60 °C
View Scheme
参考文献
Brady, Ryan M.; Khakham, Yelena; Lessene, Guillaume; Baell, Jonathan B.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 3 p. 656 - 658
反应条件
1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.25 h / 0 - 20 °C
2: trifluoroacetic acid / dichloromethane
3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 60 °C
View Scheme
参考文献
Brady, Ryan M.; Khakham, Yelena; Lessene, Guillaume; Baell, Jonathan B.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 3 p. 656 - 658
反应条件
1: trifluoroacetic acid / dichloromethane
2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 60 °C
View Scheme
参考文献
Brady, Ryan M.; Khakham, Yelena; Lessene, Guillaume; Baell, Jonathan B.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 3 p. 656 - 658
反应条件
diethyl ether; toluene
参考文献
Busch
Journal fuer Praktische Chemie (Leipzig), 1895 , vol. <2> 51, p. 126
