2-氯-4,6-二甲基吡啶-3-甲酸合成路线 (共 4 条)
反应条件
sulfuric acid; nitric acid in water; toluene
参考文献
Boehringer Ingelheim GmbH
Patent: US4167570 A1, 1979 ;
反应条件
sulfuric acid; sodium nitrite
参考文献
Dyadyuchenko; Strelkov; Mikhailichenko; Zaplishny
Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 3 p. 308 - 314
反应条件
1: 95 percent / POCl3 / 6 h / 120 °C 2: 89 percent / aq. H2SO4 / Heating 3: 60 percent / H2SO4; aq. NaNO2 View Scheme
参考文献
Chemistry of Heterocyclic Compounds, , vol. 40, # 3 p. 308 - 314
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 7 p. 2231 - 2241