二氟溴乙酸乙酯合成路线

参考文献

Golubev; Starostin; Chunikhin; Peregudov; Rodygin; Rubtsova; Slepukhin; Kuchin; Chkanikov
Russian Chemical Bulletin, 2011 , vol. 60, # 4 p. 733 - 745

625-99-01-氯-3-碘苯+

667-27-6二氟溴乙酸乙酯

135334-14-42-(3-氯苯基)-2,2-二氟乙酸乙酯

参考文献

Kreutter, Kevin D.; Lu, Tianbao; Lee, Lily; Giardino, Edward C.; Patel, Sharmila; Huang, Hui; Xu, Guozhang; Fitzgerald, Mark; Haertlein, Barbara J.; Mohan, Venkatraman; Crysler, Carl; Eisennagel, Stephen; Dasgupta, Malini; McMillan, Martin; Spurlino, John C.; Huebert, Norman D.; Maryanoff, Bruce E.; Tomczuk, Bruce E.; Damiano, Bruce P.; Player, Mark R.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 9 p. 2865 - 2870

667-27-6二氟溴乙酸乙酯+

100-51-6苯甲醇

21249-93-42,2,2-三氟乙基苯

参考文献

Duan, Jian-Xing; Chen, Quing-Yun
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 6 p. 725 - 730

54509-73-8+

667-27-6二氟溴乙酸乙酯

64906-64-5

参考文献

Morel,D.; Dawans,D.
Tetrahedron, 1977 , vol. 33, p. 1445 - 1447

667-27-6二氟溴乙酸乙酯+

651312-14-0

651312-15-1

参考文献

Lacroix, Simon; Cheguillaume, Arnaud; Gerard, Stephane; Marchand-Brynaert, Jacqueline
Synthesis, 2003 , # 16 p. 2483 - 2486

667-27-6二氟溴乙酸乙酯+

1121-86-4间氟碘苯

698378-81-3

参考文献

Kreutter, Kevin D.; Lu, Tianbao; Lee, Lily; Giardino, Edward C.; Patel, Sharmila; Huang, Hui; Xu, Guozhang; Fitzgerald, Mark; Haertlein, Barbara J.; Mohan, Venkatraman; Crysler, Carl; Eisennagel, Stephen; Dasgupta, Malini; McMillan, Martin; Spurlino, John C.; Huebert, Norman D.; Maryanoff, Bruce E.; Tomczuk, Bruce E.; Damiano, Bruce P.; Player, Mark R.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 9 p. 2865 - 2870

667-27-6二氟溴乙酸乙酯

807368-70-3

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AXYS PHARMACEUTICALS, INC.
Patent: WO2006/60494 A1, 2006 ;
Location in patent: Page/Page column 52 ;
WO 2006/060494 A1

371-41-54-氟苯酚+

667-27-6二氟溴乙酸乙酯

807368-70-3

参考文献

VIROBAY, INC.; HART, Barry; GREEN, Michael; SETTI, Eduardo; ROEPEL, Michael
Patent: WO2010/56877 A2, 2010 ;
Location in patent: Page/Page column 34-35 ;
WO 2010/056877 A2

851314-55-1

参考文献

ACTELION PHARMACEUTICALS LTD
Patent: WO2005/40120 A1, 2005 ;
Location in patent: Page/Page column 18; 31 ;
WO 2005/040120 A1

667-27-6二氟溴乙酸乙酯

87189-16-0溴二氟乙酸钾

参考文献

Li, Qiang; Lin, Jin-Hong; Deng, Zu-Yong; Zheng, Jian; Cai, Ji; Xiao, Ji-Chang
Journal of Fluorine Chemistry, 2014 , vol. 163, p. 38 - 41