trichlorophosphate in chloroform T=0 - 20°C; 1.5 h; Heating / reflux;

hydrogen bromide Erh. des Rktprod. mit Brom auf 190grad;

ClCH=N(Me)2Cl in 1,2-dichloro-ethane T=80°C; 1 h;

1: acetic acid; aqueous hydrogen peroxide 2: phosphoryl chloride; chloroform View Scheme

1: 52 percent / dichloro<1,4-bis(diphenylphosphino)butane>palladium / diethyl ether / 72 h / Heating 2: 82 percent / copper(II)sulfate*5H2O, 28 percent aqueous ammonia / 20 h / 170 - 180 °C View Scheme

PdCl2(PPh2(CH2)4PPh2) in diethyl ether 72 h; Heating;

1: ethanol 2: CuSO4; NH3 / 180 - 190 °C 3: platinum; H2SO4; acetic acid / Hydrogenation 4: aqueous hydrochloric acid; sodium nitrite / anschliessend mit Natriumhypophosphit und wss. Salzsaeure 5: aqueous hydrobromic acid 6: phosphoryl chloride / 80 °C 7: palladium; sodium acetate; ethanol / Hydrogenation View Scheme

1: 4-bromo-1-chloroisoqionoline With tert.-butyl lithium in tetrahydrofuran; hexane T=-80°C; Inert atmosphere; 2: carbon dioxide in tetrahydrofuran

1: 4-bromo-1-chloroisoqionoline With n-butyllithium in tetrahydrofuran; hexane T=-78 - -68°C; Negishi Coupling Reaction; 0.5 h; 2: With zinc dibromide in tetrahydrofuran; hexane T=-78 - 20°C; Negishi Coupling Reaction; 0.666667 h; 3: 7-[(trifluoromethyl)sulfonyl]oxyisoquinoline With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; hexane T=20 - 60°C; Negishi Coupling Reaction; 0.5 h;