1,8-二氮杂双环[5.4.0]十一碳-7-烯合成路线 （共 79 条）
反应条件
1: 1,4-dihydroxy-cyclohexane; p-toluenesulfonyl chloride With hydrogenchloride in pyridine T=0°C; Tosylation; 12 h; 2: 4-hydroxycyclohexyl 4-methylbenzenesulfonate; 1,4-cyclohexanediol di-toluenesulphonate; 1,8-diazabicyclo[5.4.0]undec-7-ene T=120°C; Elimination; 12 h;
参考文献
Cheng, Chen-Yu; Chen, Chin-Yuan; Tao, Pao-Luh
Journal of Pharmacy and Pharmacology, 1997 , vol. 49, # 9 p. 835 - 842
反应条件
in N-ethyl-N,N-diisopropylamine
参考文献
Booth, Richard John; Chatterjee, Arindam; Malone, Thomas Charles
Patent: US2004/224958 A1, 2004 ;
US 20040224958 A1
Title/Abstract Full Text Show Details
Warner-Lambert Company
Patent: US6498163 B1, 2002 ;
US 6498163 B1
反应条件
copper in Copper(I)chloride; acetonitrile
参考文献
E. R. Squibb and Sons, Inc.
Patent: US5463059 A1, 1995 ;
参考文献
BP Chemicals Limited
Patent: US4700005 A1, 1987 ;
参考文献
Mitsubishi Chemical Corporation
Patent: US5841001 A1, 1998 ;
反应条件
sodium hydrogencarbonate in benzene
参考文献
Japan Tobacco Inc.; YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.
Patent: EP396065 A1, 1990 ;
EP 0396065 A1
反应条件
in tetrahydrofuran T=25°C; further solv.; Equilibrium constant;
参考文献
Galezowski, Wlodzimierz; Jarczewski, Arnold
Canadian Journal of Chemistry, 1990 , vol. 68, # 12 p. 2242 - 2248
反应条件
in tetrahydrofuran T=25°C; further solv; Equilibrium constant;
参考文献
Galezowski, Wlodzimierz; Jarczewski, Arnold
Canadian Journal of Chemistry, 1990 , vol. 68, # 12 p. 2242 - 2248
参考文献
Merrell Dow Pharmaceuticals Inc.
Patent: US4588733 A1, 1986 ;
反应条件
in hexane; ethyl acetate; acetonitrile
参考文献
Bristol-Myers Squibb Co.
Patent: US5648385 A1, 1997 ;
