反应条件
1.1: (+)-TADDOL; Ti(O-i-Pr)4 / toluene; hexane / 12 h / -25 °C 2.1: triethylamine; DMAP / CH2Cl2 / 20 h / 20 °C 3.1: water; DDQ / CH2Cl2 / 1 h / 20 °C 4.1: 2-iodoxybenzoic acid / tetrahydrofuran; dimethylsulfoxide / 0.5 h / 20 °C 5.1: potassium tert-butoxide / tetrahydrofuran / 0.08 h / -78 °C 5.2: tetrahydrofuran / -78 - 20 °C 6.1: potassium hydroxide / methanol / 3 h / 20 °C View Scheme
参考文献
Kobayashi, Yusuke; Fukuda, Akihiro; Kimachi, Tetsutaro; Ju-ichi, Motoharu; Takemoto, Yoshiji
Tetrahedron Letters, 2004 , vol. 45, # 4 p. 677 - 680
