11beta,17,21-三羟基孕甾-4-烯-3,20-二酮 21-甲烷磺酸酯合成路线 （共 4 条）
反应条件
potassium hydroxide in ethanol Ambient temperature; Product distribution;
参考文献
Simons, S. Stoney; Merchlinsky, Michael J.; Johnson, David F.
Steroids, 1981 , vol. 37, # 3 p. 281 - 290
反应条件
acetic acid; sodium iodide
参考文献
Kocovsky; Cerny
Collection of Czechoslovak Chemical Communications, 1979 , vol. 44, # 1 p. 246 - 250
→
128887-42-3[2-[(10R,11S,13S,17R)-11,17-二羟基-10,13-二甲基-3-氧代-2,6,7,8,9,11,12,14,15,16-十氢-1H-环戊二烯并[a]菲-17-基]-2-氧代乙基]2-氨基乙酸酯盐酸盐
反应条件
1: 93 percent / NaI / acetone / 0.25 h / Heating 2: dimethylformamide / 4 h 3: 3 N HCl / dioxane / 1 h View Scheme
参考文献
Ryakhovskaya, M. I.; Popova, E. V.; Grinenko, G. S.; Terekhina, A. I.; Gritsina, G. I.; et al.
Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 3 p. 184 - 189
Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 3 p. 26 - 29
反应条件
Multi-step reaction with 2 steps 1: 93 percent / NaI / acetone / 0.25 h / Heating2: dimethylformamide / 4 h
参考文献
Ryakhovskaya, M. I.; Popova, E. V.; Grinenko, G. S.; Terekhina, A. I.; Gritsina, G. I.; et al. Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 3 p. 184 - 189Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 3 p. 26 - 29
