(1R,4S,7aR)-1-[(2S)-1-羟基-2-丙基]-7a-甲基八氢-1H-茚-4-基苯甲酸酯合成路线 （共 4 条）
反应条件
Stage #1: With pyridine; 4-(N,N-dimethlyamino)pyridine T=0 - 4°C; 24 h; Stage #2: With methanol; potassium hydroxide T=20°C; 3 h; Show Experimental Procedure
参考文献
WISCONSIN ALUMNI RESEARCH FOUNDATION Patent: US2007/191316 A1, 2007 ; Location in patent: Page/Page column 8-9; 11-12 ;
反应条件
Multi-step reaction with 2 steps 1: 99 percent / pyridine; DMAP / 0 °C2: 95 percent / KOH / ethanol; benzene
参考文献
Fall, Yagamare; Barreiro, Candida; Fernandez, Carlos; Mourino, Antonio Tetrahedron Letters, 2002 , vol. 43, # 8 p. 1433 - 1436
反应条件
Multi-step reaction with 2 steps 1: 95 percent / pyridine, ozone / methanol; CH2Cl2 / 0.42 h / -78 °C2: 1) s-collidine, 2) NaBH4 / 1) reflux, 48 h, 2) MeOH, 15 min
参考文献
Granja; Castedo; Mourino Journal of Organic Chemistry, 1993 , vol. 58, # 1 p. 124 - 131
反应条件
Multi-step reaction with 3 steps 1: 95 percent / DMAP, pyridine / 14 h / refrigerator2: 95 percent / pyridine, ozone / methanol; CH2Cl2 / 0.42 h / -78 °C3: 1) s-collidine, 2) NaBH4 / 1) reflux, 48 h, 2) MeOH, 15 min
参考文献
Granja; Castedo; Mourino Journal of Organic Chemistry, 1993 , vol. 58, # 1 p. 124 - 131
