1-甲基咪唑-5-甲酸乙酯合成路线 （共 7 条）
反应条件
in methanol 48 h; Reflux;
参考文献
Myles, Lauren; Gore, Rohitkumar G.; Gathergood, Nicholas; Connon, Stephen J.
Green Chemistry, 2013 , vol. 15, # 10 p. 2740 - 2746
反应条件
sodium hydride 1.) DMF, RT, 2.) DMF, RT, 0.5 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 42, # 7 p. 1463 - 1473
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 16 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2007/34277 A1, 2007 ;
Location in patent: Page/Page column 58 ;
反应条件
2: pyridine 3: Na2CO3; glycerol / 170 °C View Scheme
参考文献
Jones; McLaughlin
Journal of the American Chemical Society, 1949 , vol. 71, p. 2444,2447
反应条件
sodium hydroxide in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol
参考文献
Merck and Co., Inc.
Patent: US5756508 A1, 1998 ;
US 5756508 A
参考文献
Jones; McLaughlin
Journal of the American Chemical Society, 1949 , vol. 71, p. 2444,2447
反应条件
2: pyridine 3: Na2CO3; glycerol / 170 °C 4: ethanol; platinum; FeCl3 / Hydrogenation 5: SOCl2 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 71, p. 2444,2447
