5-溴-2,3-二氢苯并呋喃合成路线 （共 18 条）
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C;
参考文献
Matsunaga, Nobuyuki; Kaku, Tomohiro; Ojida, Akio; Tanaka, Toshimasa; Hara, Takahito; Yamaoka, Masuo; Kusaka, Masami; Tasaka, Akihiro
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 16 p. 4313 - 4336
反应条件
in tetrahydrofuran; hexane; water; N,N-dimethyl-formamide
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6649643 B1, 2003 ;
反应条件
Yield given. Multistep reaction;
参考文献
Alabaster, Ramon J.; Cottrell, Ian F.; Marley, Hugh; Wright, Stanley H. B.
Synthesis, 1988 , # 12 p. 950 - 952
反应条件
formic acid; triethylamine; trifluoroacetic acid in n-heptane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene
参考文献
Novo Nordisk A/S
Patent: US6043247 A1, 2000 ;
US 6043247 A
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in trifluoroacetic acid T=50°C;
参考文献
Eisai Co., Ltd.
Patent: EP1394147 A1, 2004 ;
Location in patent: Page 92 ;
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in benzene T=80°C;
参考文献
Suzuki, Hideaki; Tsutsui, Hideyuki; Kano, Atsuyuki; Katoh, Satoru; Morita, Tadashi; Matsuda, Kiyoshi; Iibuchi, Norihiro; Ogawa, Masashi
Heterocycles, 1997 , vol. 45, # 9 p. 1657 - 1661
反应条件
1: With magnesium in tetrahydrofuran 2: With boric acid trimethyl ester 3: With hydrogenchloride Further stages.;
参考文献
Li, Bi-Jie; Tian, Shi-Liang; Fang, Zhao; Shi, Zhang-Jie
Angewandte Chemie - International Edition, 2008 , vol. 47, # 6 p. 1115 - 1118
参考文献
Pfizer INC
Patent: US6387931 B1, 2002 ;
