4,6-二氯-1H-咪唑并[4,5-c]吡啶-2(3h)-酮合成路线 （共 10 条）
参考文献
MERCK and CO., INC.
Patent: WO2007/61692 A2, 2007 ;
Location in patent: Page/Page column 115 ;
WO 2007/061692 A2
反应条件
1: HNO3; H2SO4 / 20 °C
2: H2SO4 / 100 °C
3: 51 percent / Fe / 2 h / Heating
4: aq. NaOH / Heating
5: 38 percent / 72 h / Heating
6: 49 percent / aq. KOH / Heating
View Scheme
参考文献
Seley, Katherine L.; O'Daniel, Peter I.; Salima, Samer
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 12 p. 2133 - 2144
反应条件
1: 51 percent / Fe / 2 h / Heating
2: aq. NaOH / Heating
3: 38 percent / 72 h / Heating
4: 49 percent / aq. KOH / Heating
View Scheme
参考文献
Seley, Katherine L.; O'Daniel, Peter I.; Salima, Samer
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 12 p. 2133 - 2144
反应条件
potassium hydroxide
Heating;
参考文献
Seley, Katherine L.; O'Daniel, Peter I.; Salima, Samer
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 12 p. 2133 - 2144
反应条件
1: CF3COOH; aq. H2O2 / 6.5 h / Heating
2: HNO3; H2SO4 / 160 °C
3: AcOH; Fe / Heating
4: HNO3; H2SO4 / 20 °C
5: H2SO4 / 100 °C
6: 51 percent / Fe / 2 h / Heating
7: aq. NaOH / Heating
8: 38 percent / 72 h / Heating
9: 49 percent / aq. KOH / Heating
View Scheme
参考文献
Seley, Katherine L.; O'Daniel, Peter I.; Salima, Samer
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 12 p. 2133 - 2144
反应条件
1: HNO3; H2SO4 / 160 °C
2: AcOH; Fe / Heating
3: HNO3; H2SO4 / 20 °C
4: H2SO4 / 100 °C
5: 51 percent / Fe / 2 h / Heating
6: aq. NaOH / Heating
7: 38 percent / 72 h / Heating
8: 49 percent / aq. KOH / Heating
View Scheme
参考文献
Seley, Katherine L.; O'Daniel, Peter I.; Salima, Samer
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 12 p. 2133 - 2144
反应条件
1: H2SO4 / 100 °C
2: 51 percent / Fe / 2 h / Heating
3: aq. NaOH / Heating
4: 38 percent / 72 h / Heating
5: 49 percent / aq. KOH / Heating
View Scheme
参考文献
Seley, Katherine L.; O'Daniel, Peter I.; Salima, Samer
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 12 p. 2133 - 2144
反应条件
1: AcOH; Fe / Heating
2: HNO3; H2SO4 / 20 °C
3: H2SO4 / 100 °C
4: 51 percent / Fe / 2 h / Heating
5: aq. NaOH / Heating
6: 38 percent / 72 h / Heating
7: 49 percent / aq. KOH / Heating
View Scheme
参考文献
Seley, Katherine L.; O'Daniel, Peter I.; Salima, Samer
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 12 p. 2133 - 2144
反应条件
1: aq. NaOH / Heating
2: 38 percent / 72 h / Heating
3: 49 percent / aq. KOH / Heating
View Scheme
参考文献
Seley, Katherine L.; O'Daniel, Peter I.; Salima, Samer
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 12 p. 2133 - 2144
反应条件
1: 38 percent / 72 h / Heating
2: 49 percent / aq. KOH / Heating
View Scheme
参考文献
Seley, Katherine L.; O'Daniel, Peter I.; Salima, Samer
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 12 p. 2133 - 2144
