3-甲基-4-苯基-1-丁烯合成路线 （共 61 条）
参考文献
Murayama, Eigoro; Kikuchi, Toshihiro; Sasaki, Kotaro; Sootome, Norio; Sato, Tadashi
Chemistry Letters, 1984 , p. 1897 - 1900
反应条件
phosphoric acid, fully deuterated
T=230 - 240°C; 3 h; Yield given. Title compound not separated from byproducts;
参考文献
Sakhabutdinov, A. G.; Usmanova, A. G.; Frolov, P. A.; Kushnarev, D. F.; Schmidt, F. K.
Journal of Organic Chemistry USSR (English Translation), 1988 , vol. 24, # 8 p. 1452 - 1455
Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 8 p. 1610 - 1614
反应条件
(i), (ii) POCl3, Py; Multistep reaction;
参考文献
Mazzocchi,P.H.; Lustig,R.S.
Journal of the American Chemical Society, 1975 , vol. 97, # 13 p. 3707 - 3713
反应条件
1.1: triphenylphosphine; 1H-imidazole; bromine / dichloromethane / 27 h / 20 °C / |Inert atmosphere
2.1: potassium carbonate / acetone / 24 h / |Reflux; |Inert atmosphere
3.1: (NH4)6[Mo7O24]*4H2O; dihydrogen peroxide / methanol; water / 2.5 h / 0 - 20 °C / |Inert atmosphere
4.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / |Inert atmosphere
4.2: 20 h / 20 °C / |Inert atmosphere
5.1: N,N,N',N,-tetramethylethylenediamine; iron (III) acetylacetonate; CPME / diethyl ether / 18 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Denmark, Scott E.; Cresswell, Alexander J.
Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12593 - 12628
反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / |Inert atmosphere
1.2: 20 h / 20 °C / |Inert atmosphere
2.1: N,N,N',N,-tetramethylethylenediamine; iron (III) acetylacetonate; CPME / diethyl ether / 18 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Denmark, Scott E.; Cresswell, Alexander J.
Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12593 - 12628
反应条件
1.1: sodium tetrahydroborate / methanol / 65 h / 4 - 20 °C / |Inert atmosphere
2.1: triphenylphosphine; 1H-imidazole; bromine / dichloromethane / 27 h / 20 °C / |Inert atmosphere
3.1: potassium carbonate / acetone / 24 h / |Reflux; |Inert atmosphere
4.1: (NH4)6[Mo7O24]*4H2O; dihydrogen peroxide / methanol; water / 2.5 h / 0 - 20 °C / |Inert atmosphere
5.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / |Inert atmosphere
5.2: 20 h / 20 °C / |Inert atmosphere
6.1: N,N,N',N,-tetramethylethylenediamine; iron (III) acetylacetonate; CPME / diethyl ether / 18 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Denmark, Scott E.; Cresswell, Alexander J.
Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12593 - 12628
反应条件
1.1: potassium carbonate / acetone / 24 h / |Reflux; |Inert atmosphere
2.1: (NH4)6[Mo7O24]*4H2O; dihydrogen peroxide / methanol; water / 2.5 h / 0 - 20 °C / |Inert atmosphere
3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / |Inert atmosphere
3.2: 20 h / 20 °C / |Inert atmosphere
4.1: N,N,N',N,-tetramethylethylenediamine; iron (III) acetylacetonate; CPME / diethyl ether / 18 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Denmark, Scott E.; Cresswell, Alexander J.
Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12593 - 12628
反应条件
1.1: (NH4)6[Mo7O24]*4H2O; dihydrogen peroxide / methanol; water / 2.5 h / 0 - 20 °C / |Inert atmosphere
2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / |Inert atmosphere
2.2: 20 h / 20 °C / |Inert atmosphere
3.1: N,N,N',N,-tetramethylethylenediamine; iron (III) acetylacetonate; CPME / diethyl ether / 18 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Denmark, Scott E.; Cresswell, Alexander J.
Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12593 - 12628
参考文献
Murayama, Eigoro; Kikuchi, Toshihiro; Sasaki, Kotaro; Sootome, Norio; Sato, Tadashi
Chemistry Letters, 1984 , p. 1897 - 1900
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine in hexane
T=19°C; 24 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Babin, D.; Fourneron, J. D.; Harwood, L. M.; Julia, M.
Tetrahedron, 1981 , vol. 37, p. 325 - 332
