1-[2,4-双(苯甲酰氧基)苯基]乙酮合成路线 （共 13 条）
反应条件
1: boron trifluoride diethyl etherate / 1,4-dioxane / 20 °C / Inert atmosphere 2: sodium hydroxide / methanol / 0.25 h / 20 °C View Scheme
参考文献
Sano, Shigeki; Okubo, Yoshinori; Handa, Atsushi; Nakao, Michiyasu; Kitaike, Syuji; Nagao, Yoshimitsu; Kakegawa, Hisao
Chemical and Pharmaceutical Bulletin, 2011 , vol. 59, # 7 p. 885 - 888
反应条件
1: potassium carbonate / acetone / Heating 2: potassium carbonate / H2O 3: Alkaline hydrolysis View Scheme
参考文献
Le Floc'H, Yves; Lefeuvre, Martine
Tetrahedron Letters, 1986 , vol. 27, # 24 p. 2751 - 2752
反应条件
anhydrous sodium benzoate T=200°C;
参考文献
Looker; Hanneman
Journal of Organic Chemistry, 1957 , vol. 22, p. 1237
参考文献
Dunne et al.
Journal of the Chemical Society, 1950 , p. 1252,1257
反应条件
pyridine in diethyl ether
T=0°C; 1 h;
参考文献
Wu; Cole; Davidson; Dailey; Doring; Fedorchuk; Loch III; Thomas; Blosser; Borrelli; Kinsolving; Parker; Strand; Watkins
Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 183 - 192
反应条件
pyridine; trichlorophosphate
T=20°C; Cooling;
参考文献
Sheikh, Javed; Parvez, Ali; Juneja, Harjeet; Ingle, Vishwas; Chohan, Zahid; Youssoufi, Moulay; Ben Hadda, Taibi
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1390 - 1399
反应条件
1: 75 percent / K2CO3 / acetone / 48 h / Heating
2: 85 percent / NaOAc, glacial acetic acid / 16 h / Heating
3: 72 percent / NaOH / H2O; propan-2-ol / 2 h / 70 °C
5: 86 percent / H2, HOAc / 10percentPd/C / methanol
View Scheme
参考文献
Wu; Cole; Davidson; Dailey; Doring; Fedorchuk; Loch III; Thomas; Blosser; Borrelli; Kinsolving; Parker; Strand; Watkins
Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 183 - 192
反应条件
1: 75 percent / phenyltrimethylammonium tribromide / tetrahydrofuran / 6 h / 20 °C
2: 79 percent / acetonitrile / 48 h / 20 °C
3: NaH / tetrahydrofuran / Heating
4: 274 mg / H2SO4 / acetic acid / 1.5 h / 60 °C
5: 87 percent / NaOH; H2O / ethanol / 2 h / 60 °C
View Scheme
参考文献
Fougerousse, Andre; Gonzalez, Emmanuel; Brouillard, Raymond
Journal of Organic Chemistry, 2000 , vol. 65, # 2 p. 583 - 586
反应条件
pyridine; potassium hydroxide
T=50°C; 0.333333 h;
参考文献
Cunningham, Bernadette D. M.; Lowe, Philip R.; Threadgill, Michael D.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1989 , p. 1275 - 1284
反应条件
potassium carbonate in acetone
48 h; Heating;
参考文献
Wu; Cole; Davidson; Dailey; Doring; Fedorchuk; Loch III; Thomas; Blosser; Borrelli; Kinsolving; Parker; Strand; Watkins
Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 183 - 192
