1-(苄氧基)-3-乙基苯合成路线 （共 6 条）
反应条件
1: With potassium carbonate in acetonitrile
T=20°C; 5 h;
2: With hydrogenchloride in water; acetonitrile
Product distribution / selectivity;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/66136 A1, 2005 ;
Location in patent: Page/Page column 71 ;
WO 2005/066136 A1
反应条件
1: 1-iodo-propane With manganese bromide tetrahydrate; N,N'-dimethyl-N,N'-propyleneurea; diethylzinc; copper(l) chloride in tetrahydrofuran
T=20°C; 4 h;
2: 3-benzyloxy-iodobenzene With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in tetrahydrofuran
2.5 h; Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/66136 A1, 2005 ;
Location in patent: Page/Page column 64-65 ;
WO 2005/066136 A1
反应条件
1: ethyl iodide With manganese bromide tetrahydrate; N,N'-dimethyl-N,N'-propyleneurea; diethylzinc; copper(l) chloride in tetrahydrofuran
4 h;
2: 3-benzyloxy-iodobenzene With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in tetrahydrofuran
2.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/66136 A1, 2005 ;
Location in patent: Page/Page column 62-63 ;
WO 2005/066136 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=50°C; 48 h;
参考文献
GLAXO GROUP LIMITED; XIANG, Jianing; LIN, Xichen; REN, Feng; DENG, Guanghui
Patent: WO2010/148650 A1, 2010 ;
Location in patent: Page/Page column 49-50 ;
WO 2010/148650 A1
反应条件
1: With tris-(dibenzylideneacetone)dipalladium(0); tri-cyclo-hexyl-phosphine in 1,4-dioxane
T=20°C; 0.25 h; Inert atmosphere;
2: With formic acid in 1,4-dioxane
T=80°C; Inert atmosphere; chemoselective reaction;
参考文献
Shen, Ruwei; Chen, Tieqiao; Zhao, Yalei; Qiu, Renhua; Zhou, Yongbo; Yin, Shuangfeng; Wang, Xiangbo; Goto, Midori; Han, Li-Biao
Journal of the American Chemical Society, 2011 , vol. 133, # 42 p. 17037 - 17044
参考文献
Dow Chem. Co.
Patent: US2121724 , 1937 ;
