4-(4-(苄氧基)苯基)丁酸合成路线 （共 8 条）
反应条件
1.1: N,O-dimethylhydroxylamine hydrochloride; HOBT; EDAC 1.2: 80 percent / DIBAL / tetrahydrofuran / -78 °C 2.1: CH2Cl2 3.1: H2 / Pd(OH)2 / methanol; ethyl acetate 4.1: 100 percent / aq. NaOH / methanol View Scheme
参考文献
Chu, Lin; Hutchins, Jennifer E.; Weber, Ann E.; Lo, Jane-Ling; Yang, Yi-Tien; Cheng, Kang; Smith, Roy G.; Fisher, Michael H.; Wyvratt, Matthew J.; Goulet, Mark T.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 509 - 513
反应条件
hydrogenchloride; sodium hydroxide in methanol; dichloromethane
参考文献
Merck and Co., Inc.
Patent: US5756507 A1, 1998 ;
US 5756507 A
反应条件
1: With sodium hydride in N,N-dimethyl-formamide
2: With sodium hydroxide in methanol
参考文献
Chu, Lin; Lo, Jane-Ling; Yang, Yi-Tien; Cheng, Kang; Smith, Roy G.; Fisher, Michael H.; Wyvratt, Matthew J.; Goulet, Mark T.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 515 - 517
反应条件
1.1: 98 percent / BBr3 / CH2Cl2
2.1: NaH / dimethylformamide
2.2: aq. NaOH / methanol
View Scheme
参考文献
Chu, Lin; Hutchins, Jennifer E.; Weber, Ann E.; Lo, Jane-Ling; Yang, Yi-Tien; Cheng, Kang; Smith, Roy G.; Fisher, Michael H.; Wyvratt, Matthew J.; Goulet, Mark T.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 509 - 513
反应条件
(i) NaOEt, (ii) /BRN= 605865/, (iii) KOH; Multistep reaction;
参考文献
Bullock
Journal of medicinal chemistry, 1968 , vol. 11, # 3 p. 419 - 424
参考文献
Cevasco, Giorgio; Thea, Sergio
Gazzetta Chimica Italiana, 1997 , vol. 127, # 5 p. 269 - 272
反应条件
1: With O,N-dimethyl-hydroxylamine hydrochloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride
2: With diisobutylaluminium hydride in tetrahydrofuran
T=-78°C;
参考文献
Chu, Lin; Hutchins, Jennifer E.; Weber, Ann E.; Lo, Jane-Ling; Yang, Yi-Tien; Cheng, Kang; Smith, Roy G.; Fisher, Michael H.; Wyvratt, Matthew J.; Goulet, Mark T.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 509 - 513
反应条件
(i) SOCl2, (ii) aq. H2O2, Py, (iii) /BRN= 1565260/; Multistep reaction;
参考文献
Bullock
Journal of medicinal chemistry, 1968 , vol. 11, # 3 p. 419 - 424
