3-甲基-3H-咪唑并[4,5-b]吡啶合成路线 （共 6 条）
反应条件
sodium hydride in tetrahydrofuran T=0°C; Methylation;
参考文献
Journal of the American Chemical Society, , vol. 121, # 51 p. 12186 - 12187
反应条件
1: 1H-imidazo[4,5-b]-pyridine With sodium hydride in N,N-dimethyl-formamide T=20°C; 2: methyl iodide in N,N-dimethyl-formamide T=50°C;
参考文献
Yoshizawa, Hidenori; Itani, Hikaru; Ishikura, Koji; Irie, Tadashi; Yokoo, Katsuki; Kubota, Tadatoshi; Minami, Kyoji; Iwaki, Tsutomu; Miwa, Hideaki; Nishitani, Yasuhiro
Journal of Antibiotics, 2002 , vol. 55, # 11 p. 975 - 992
反应条件
acetic acid in dichloromethane T=150°C; 0.5 h; Microwave irradiation;
参考文献
Macdonald, Jonathan; Oldfield, Victoria; Bavetsias, Vassilios; Blagg, Julian
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 14 p. 2335 - 2347
反应条件
1: palladium 10 on activated carbon; hydrazine hydrate / ethylene glycol dimethyl ether / 1.5 h / 40 °C / |Inert atmosphere; |Reflux 2: acetic acid / dichloromethane / 0.5 h / 150 °C / |Microwave irradiation View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 14 p. 2335 - 2347
反应条件
bromine in water; acetic acid 5 h; Heating;
参考文献
Yutilov; Lopatinskaya; Smolyar; Gres'Ko
Russian Journal of Organic Chemistry, 2005 , vol. 41, # 3 p. 450 - 454
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=-78°C; 1 h; 2: With N-chloro-succinimide in tetrahydrofuran; n-heptane; ethylbenzene T=-78 - 20°C;
参考文献
Jahnke, Mareike C.; Brackemeyer, Dirk; Pape, Tania; Hahn, F. Ekkehardt
Heteroatom Chemistry, 2011 , vol. 22, # 3-4 p. 476 - 490
