N-{[(2-甲基-2-丙基)氧基]羰基}-L-蛋氨酰-L-亮氨酸甲酯合成路线 （共 8 条）
反应条件
triethylamine; dicyclohexyl-carbodiimide in dichloromethane
Ambient temperatureovernight;
参考文献
Freidinger, Roger M.; Perlow, Debra Schwenk; Veber, Daniel F.
Journal of Organic Chemistry, 1982 , vol. 47, # 1 p. 104 - 109
反应条件
in ethyl acetate; N,N-dimethyl-formamide
参考文献
Mori, Hiroshi
Patent: EP1498421 A1, 2005 ;
反应条件
alcalase cross-linked enzyme aggregates
T=50°C; 48 h; Molecular sieveEnzymatic reaction;
参考文献
Nuijens, Timo; Piva, Elena; Kruijtzer, John A. W.; Rijkers, Dirk T. S.; Liskamp, Rob M. J.; Quaedflieg, Peter J. L. M.
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 7 p. 1039 - 1044
反应条件
triethylamine; dicyclohexyl-carbodiimide in dichloromethane
1) -5 deg C, 3 h 2) refrigerator, 48 h 3) room temperature, 4 h;
参考文献
Abou Ghalia, M. H.; Salem, Ezzeldin M.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 2 p. 135 - 138
反应条件
in N,N-dimethyl-formamide
T=-5 - 20°C;
参考文献
Spisani, Susanna; Turchetti, Marianna; Varani, Katia; Falzarano, Sofia; Cavicchioni, Giorgio
European Journal of Pharmacology, 2003 , vol. 469, # 1-3 p. 13 - 19
反应条件
1: alcalase cross-linked enzyme aggregates / 20 h / 50 °C / Molecular sieve
2: alcalase cross-linked enzyme aggregates / 48 h / 50 °C / Molecular sieve; Enzymatic reaction
View Scheme
参考文献
Nuijens, Timo; Piva, Elena; Kruijtzer, John A. W.; Rijkers, Dirk T. S.; Liskamp, Rob M. J.; Quaedflieg, Peter J. L. M.
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 7 p. 1039 - 1044
反应条件
1: alcalase cross-linked enzyme aggregates / 20 h / 50 °C / Molecular sieve
2: alcalase cross-linked enzyme aggregates / 48 h / 50 °C / Molecular sieve; Enzymatic reaction
View Scheme
参考文献
Nuijens, Timo; Piva, Elena; Kruijtzer, John A. W.; Rijkers, Dirk T. S.; Liskamp, Rob M. J.; Quaedflieg, Peter J. L. M.
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 7 p. 1039 - 1044
反应条件
1: N-Boc-L-Met-L-Leu methyl ester With sodium hydroxide
2: formic acid With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
T=20°C; 3 h;
参考文献
Spisani, Susanna; Turchetti, Marianna; Varani, Katia; Falzarano, Sofia; Cavicchioni, Giorgio
European Journal of Pharmacology, 2003 , vol. 469, # 1-3 p. 13 - 19
