反应条件
1: 68 percent / (i-Pr)2NEt / dioxane; H2O
2: Et3N / dimethylformamide; dioxane / 1 h / -10 °C
3: Et3N / dimethylformamide; dioxane / 2 h / 25 °C
4: H2 / 5percent Pd/C / dioxane / 20 h / Ambient temperature
5: N,N-dimethyl-acetamide / 120 h / 25 °C
View Scheme
参考文献
Piper; Montgomery; Sirotnak; Chello
Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 182 - 187
