N-叔丁基-1-甲基环丙烷-1-磺酰胺合成路线 （共 4 条）
反应条件
1: N-(tert-butyl)-3-chloropropane-1-sulfonamide With n-butyllithium in tetrahydrofuran; hexane T=-69 - 20°C; 4.33333 h; 2: methyl iodide in tetrahydrofuran; hexane T=-65 - 50°C; 4.66667 h;
参考文献
Bristol-Myers Squibb Company; Zheng, Zhizhen Barbara; D'Andrea, Stanley
Patent: US2013/102589 A1, 2013 ;
Location in patent: Paragraph 0072; 0073 ;
反应条件
1: N-(tert-butyl)-3-chloropropane-1-sulfonamide With n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C; 1.5 h; 2: With n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C; 2 h; 3: methyl iodide With water; ammonium chloride more than 3 stages;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/14173 A1, 2008 ;
Location in patent: Page/Page column 27 ;
US 20080014173 A1
反应条件
1: N-(tert-butyl)cyclopropanesulfonamide With n-butyllithium in tetrahydrofuran T=-78 - 6°C; 0.333333 h; 2: methyl iodide in tetrahydrofuran T=-78°C; 2 h;
参考文献
WO2012/40040 A1, ;
Page/Page column 35-36 ;
WO 2012/040040 A1
反应条件
trifluoroacetic acid T=20°C; 16 h;
参考文献
Hewawasam, Piyasena; Ding, Min; Sun, Li-Qiang; Scola, Paul Michael
Patent: US2007/10455 A1, 2007 ;
Location in patent: Page/Page column 28 ;
