3-氨基-5-溴吡啶-2-甲酰胺合成路线 （共 10 条）
反应条件
sodium tetrahydroborate; nickel diacetate in methanol T=20°C; 0.333333 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/87488 A2, 2007 ;
Location in patent: Page/Page column 23 ;
反应条件
water; iron; ammonium chloride in methanol T=100°C; 20 h;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1757594 A1, 2007 ;
Location in patent: Page/Page column 77 ;
EP 1757594 A1
反应条件
1: dimethylformamide / 120 °C 2: SnCl2 / methanol / 50 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 13 p. 3608 - 3612
反应条件
1: POBr3 / toluene / 80 °C 2: dimethylformamide / 120 °C 3: SnCl2 / methanol / 50 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 13 p. 3608 - 3612
反应条件
1: With sodium hydroxide in water 5 h; Reflux; 2: With hydrogenchloride T=0°C; pH=7;
参考文献
Endo Pharmaceuticals Inc.; Smith, Roger Astbury; Venkatesan, Aranapakam; Bejugam, Mallesham; Hoshalli, Subramanya; Nanduri, Srinivas
Patent: US2014/38952 A1, 2014 ;
Location in patent: Page/Page column 0180-0181 ;
反应条件
1.1: NOBF4 / CH2Cl2 1.2: toluene / 100 °C 2.1: aq. HCl / 100 °C View Scheme
参考文献
Kuduk, Scott D.; DiPardo, Robert M.; Chang, Ronald K.; Di Marco, Christina N.; Murphy, Kathy L.; Ransom, Richard W.; Reiss, Duane R.; Tang, Cuyue; Prueksaritanont, Thomayant; Pettibone, Douglas J.; Bock, Mark G.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3608 - 3612
反应条件
1: sodium hydroxide; water / 5 h / |Reflux 2: 2.5 h / 200 °C 3: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 10 h / 130 °C View Scheme
参考文献
Endo Pharmaceuticals Inc.; Smith, Roger Astbury; Venkatesan, Aranapakam; Bejugam, Mallesham; Hoshalli, Subramanya; Nanduri, Srinivas
Patent: US2014/38952 A1, 2014 ;
反应条件
NOBF4 in dichloromethane
T=23°C; 18 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/87488 A2, 2007 ;
Location in patent: Page/Page column 23 ;
反应条件
1.1: NOBF4 / CH2Cl2
1.2: toluene / 100 °C
2.1: aq. HCl / 100 °C
3.1: EDCI; TEA / dimethylformamide
View Scheme
参考文献
Kuduk, Scott D.; DiPardo, Robert M.; Chang, Ronald K.; Di Marco, Christina N.; Murphy, Kathy L.; Ransom, Richard W.; Reiss, Duane R.; Tang, Cuyue; Prueksaritanont, Thomayant; Pettibone, Douglas J.; Bock, Mark G.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3608 - 3612
反应条件
1.1: NOBF4 / CH2Cl2
1.2: toluene / 100 °C
2.1: aq. HCl / 100 °C
3.1: EDCI; TEA / dimethylformamide
4.1: LiAlH4 / diethyl ether / -78 °C
View Scheme
参考文献
Kuduk, Scott D.; DiPardo, Robert M.; Chang, Ronald K.; Di Marco, Christina N.; Murphy, Kathy L.; Ransom, Richard W.; Reiss, Duane R.; Tang, Cuyue; Prueksaritanont, Thomayant; Pettibone, Douglas J.; Bock, Mark G.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3608 - 3612
