1-N-Boc-4-(3,4-二氯苯基)-4-氰基哌啶合成路线 （共 3 条）
反应条件
caesium carbonate in dimethyl sulfoxide
T=20°C; 92 h;
参考文献
ASTRAZENECA AB
Patent: WO2004/56771 A1, 2004 ;
Location in patent: Page 19 ;
WO 2004/056771 A1
反应条件
potassium hexamethylsilazane in toluene
T=60°C; 16 h;
参考文献
ABBVIE INC.; BAYBURT, Erol K.; CLAPHAM, Bruce; COX, Phil B.; DAANEN, Jerome F.; GOMTSYAN, Arthur; KORT, Michael E.; KYM, Philip R.; VOIGHT, Eric A.; SCHMIDT, Robert G.; DART, Michael J.; GFESSER, Gregory
Patent: WO2013/62964 A2, 2013 ;
Location in patent: Paragraph 1345; 1346 ;
反应条件
triethylamine in tetrahydrofuran
T=20°C; 2 h; Inert atmosphere;
参考文献
Kazmierski, Wieslaw M.; Aquino, Christopher; Chauder, Brian A.; Deanda, Felix; Ferris, Robert; Jones-Hertzog, Deborah K.; Kenakin, Terrence; Koble, Cecilia S.; Watson, Christian; Wheelan, Pat; Yang, Hanbiao; Youngman, Michael
Journal of Medicinal Chemistry, 2008 , vol. 51, # 20 p. 6538 - 6546
