4-氨基-4-(3-溴-苯基)-哌啶-1-羧酸叔丁酯合成路线 （共 4 条）
反应条件
ammonia; hydrogen; nickel in ethanol
T=20°C; P=2585.81 Torr; 24 h;
参考文献
ASTRAZENECA AB
Patent: WO2004/56771 A1, 2004 ;
Location in patent: Page 23 ;
WO 2004/056771 A1
反应条件
1.1: Bu4N(1+)*HSO4(1-) / aq. NaOH
2.1: 1-chloroethylchloroformate / 1,2-dichloro-ethane / 85 °C
2.2: aq. NaOH / methanol
3.1: BH3-THF / 40 °C
View Scheme
参考文献
Liu, Jian; Jian, Tianying; Sebhat, Iyassu; Nargund, Ravi
Tetrahedron Letters, 2006 , vol. 47, # 29 p. 5115 - 5117
反应条件
1.1: Bu4N(1+)*HSO4(1-) / aq. NaOH
2.1: 1-chloroethylchloroformate / 1,2-dichloro-ethane / 85 °C
2.2: aq. NaOH / methanol
3.1: BH3-THF / 40 °C
View Scheme
参考文献
Liu, Jian; Jian, Tianying; Sebhat, Iyassu; Nargund, Ravi
Tetrahedron Letters, 2006 , vol. 47, # 29 p. 5115 - 5117
反应条件
1.1: 1-chloroethylchloroformate / 1,2-dichloro-ethane / 85 °C
1.2: aq. NaOH / methanol
2.1: BH3-THF / 40 °C
View Scheme
参考文献
Liu, Jian; Jian, Tianying; Sebhat, Iyassu; Nargund, Ravi
Tetrahedron Letters, 2006 , vol. 47, # 29 p. 5115 - 5117
