3-{4-[2-(5-甲基-2-苯基-1,3-恶唑-4-基)乙氧基]-1H-吲唑-1-基}丙酸合成路线 （共 13 条）
反应条件
1: caesium carbonate / N,N-dimethyl-formamide
2: potassium hydroxide / tetrahydrofuran; water / 3 h
View Scheme
参考文献
Saenz, James; Mitchell, Mark; Bahmanyar, Sami; Stankovic, Nebojsa; Perry, Michael; Craig-Woods, Bridgette; Kline, Billie; Yu, Shu; Albizati, Kim
Organic Process Research and Development, 2007 , vol. 11, # 1 p. 30 - 38
反应条件
1: caesium carbonate / acetonitrile / 18 h / 20 - 60 °C
2: hydrogen; palladium on activated charcoal / methanol; ethyl acetate
3: potassium acetate; acetic anhydride / benzene
4: caesium carbonate / N,N-dimethyl-formamide
5: potassium hydroxide / tetrahydrofuran; water / 3 h
View Scheme
参考文献
Saenz, James; Mitchell, Mark; Bahmanyar, Sami; Stankovic, Nebojsa; Perry, Michael; Craig-Woods, Bridgette; Kline, Billie; Yu, Shu; Albizati, Kim
Organic Process Research and Development, 2007 , vol. 11, # 1 p. 30 - 38
反应条件
1.1: tert-butyl methyl ether / 760.05 Torr / |Heating; |Inert atmosphere
1.2: 36 h / 65 °C / |Heating; |Inert atmosphere
2.1: potassium hydroxide / tetrahydrofuran; water / 3 h
View Scheme
参考文献
Saenz, James; Mitchell, Mark; Bahmanyar, Sami; Stankovic, Nebojsa; Perry, Michael; Craig-Woods, Bridgette; Kline, Billie; Yu, Shu; Albizati, Kim
Organic Process Research and Development, 2007 , vol. 11, # 1 p. 30 - 38
