6-氯-2-甲基-3-氰基吡啶合成路线 （共 8 条）
反应条件
trichlorophosphate 1.5 h; Heating;
参考文献
Singh; Lesher; Brundage
Synthesis, 1991 , # 10 p. 894 - 896
反应条件
1: With diisobutylaluminium hydride in dichloromethane T=0°C; 1 h; 2: With water; citric acid in dichloromethane 1 h; 3: With sodium hydrogencarbonate in dichloromethane; water
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/58923 A1, 2009 ;
Location in patent: Page/Page column 16 ;
WO 2009/058923 A1
反应条件
in methanol 0.5 h; Heating;
参考文献
Singh; Lesher; Brundage
Synthesis, 1991 , # 10 p. 894 - 896
反应条件
sodium methylate in methanol
参考文献
Sterling Drug Inc.
Patent: US4657915 A1, 1987 ;
反应条件
5 Pd(II)/C(eggshell); ammonium formate in methanol T=20°C; 12 h;
参考文献
CUSHMAN, Mark S.; KISELEV, Evgeny A.; MORRELL, Andrew E.
Patent: US2014/18360 A1, 2014 ;
Location in patent: Paragraph 0162 ;
反应条件
1: ammonium formate; 5 palladium on charcoal / methanol / 12 h / 23 °C 2: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / 1,2-dichloro-ethane / 9 h / |Reflux View Scheme
反应条件
caesium carbonate in N,N-dimethyl-formamide T=20°C; 16 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/58919 A1, 2009 ;
Location in patent: Page/Page column 27 ;
WO 2009/058919 A1
