2-溴-1-(氯甲基)-4-甲氧基苯合成路线 （共 6 条）
反应条件
1: (i) NaOEt, EtOH, (ii) /BRN= 2519947/ 2: aq. NaOH 3: N,N-dimethyl-acetamide / 150 °C 4: NaNH2 / liquid ammonia View Scheme
参考文献
Skorcz,J.A.; Robertson,J.E.
Journal of Medicinal Chemistry, 1965 , vol. 8, p. 255 - 257
反应条件
hydrogenchloride in water
T=40°C; 2.66667 h; Title compound not separated from byproducts;
参考文献
Heemstra, Jennifer M.; Kerrigan, Sean A.; Doerge, Daniel R.; Helferich, William G.; Boulanger, William A.
Organic Letters, 2006 , vol. 8, # 24 p. 5441 - 5443
参考文献
Skorcz,J.A.; Robertson,J.E.
Journal of Medicinal Chemistry, 1965 , vol. 8, p. 255 - 257
反应条件
formaldehyd
Einleiten von HCl;
参考文献
Lythgoe et al.
Journal of the Chemical Society, 1956 , p. 4060,4063
反应条件
hydrogenchloride; formaldehyd
参考文献
Lythgoe et al.
Journal of the Chemical Society, 1956 , p. 4060,4063
反应条件
sodium bromide in acetone
16 h; Reflux;
参考文献
Hsieh, Jen-Chieh; Cheng, An-Yi; Fu, Jun-Hao; Kang, Ting-Wei
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 31 p. 6404 - 6409
