(5-丁氧基吡啶-2-基)甲醇合成路线 （共 5 条）
反应条件
sodium methylate in methanol; dimethyl sulfoxide
参考文献
Meiji Seika Kaisha, Ltd.
Patent: US4189489 A1, 1980 ;
反应条件
potassium hydroxide in methanol
2 h; Heating;
参考文献
Oehlke, J.; Schroetter, E.; Dove, S.; Schick, H.; Niedrich, H.
Pharmazie, 1983 , vol. 38, # 9 p. 591 - 596
反应条件
1: 1) Na / 1) CH3OH, DMSO; 2) 6 h, 50 deg C
2: 1) H2O2 / 1) CH3COOH, H2O, 1 h 40 deg C, 1 h 50 deg C, 1 h 70 deg C, 1 h 80 deg C, 1 h 90 deg C, 17 h 100 deg C, 2) 3 h, 140 deg C
3: 64 percent / KOH / methanol / 2 h / Heating
View Scheme
参考文献
Oehlke, J.; Schroetter, E.; Dove, S.; Schick, H.; Niedrich, H.
Pharmazie, 1983 , vol. 38, # 9 p. 591 - 596
反应条件
1: 1) H2O2 / 1) CH3COOH, H2O, 1 h 40 deg C, 1 h 50 deg C, 1 h 70 deg C, 1 h 80 deg C, 1 h 90 deg C, 17 h 100 deg C, 2) 3 h, 140 deg C
2: 64 percent / KOH / methanol / 2 h / Heating
View Scheme
参考文献
Oehlke, J.; Schroetter, E.; Dove, S.; Schick, H.; Niedrich, H.
Pharmazie, 1983 , vol. 38, # 9 p. 591 - 596
反应条件
potassium permanganate in water
1) 30 min, 5-10 deg C; 2) 30 min, 50 deg C;
参考文献
Oehlke, J.; Schroetter, E.; Dove, S.; Schick, H.; Niedrich, H.
Pharmazie, 1983 , vol. 38, # 9 p. 591 - 596
