2-氨基苯并噻唑-6-甲酸甲酯合成路线 （共 8 条）
反应条件
bromine in acetic acid 2 h;
参考文献
Naim, S Shawkat; Singh, Sudhir K; Sharma, Satyavan
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 5 p. 494 - 498
反应条件
bromine; acetic acid
参考文献
Yakugaku Zasshi, , vol. 70, p. 271,276
Chem.Abstr., , p. 10212
参考文献
WO2010/62171 A2, ;
Page/Page column 156 ;
反应条件
sodium hydroxide in ethanol T=20°C; 4 h;
参考文献
Kitagawa, Hideo; Ozawa, Tomohiro; Takahata, Sho; Iida, Maiko
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 17 p. 4982 - 4986
反应条件
1: With lithium hydroxide; water in tetrahydrofuran T=0 - 20°C; 2: With hydrogenchloride; water in tetrahydrofuran pH=2;
参考文献
IRM LLC
Patent: WO2008/124393 A1, 2008 ;
Location in patent: Page/Page column 33-34 ;
WO 2008/124393 A1
反应条件
tert.-butylnitrite; copper(ll) bromide in acetonitrile
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 7 p. 2324 - 2328
反应条件
1: 1.) 85percent H3PO4, NaNO2, 2.) H3PO2 / 1.) H2O, -8 - -4 deg C, 2.) -4 deg C to room temperature
2: NH2NH2*H2O / aq. ethanol / Ambient temperature
View Scheme
参考文献
Chedekel, Miles R.; Sharp, Dale E.; Jeffery, Gary A.
Synthetic Communications, 1980 , vol. 10, # 3 p. 167 - 174
反应条件
phosphoric acid; hypophosphorous acid; sodium nitrite
1.) H2O, -8 - -4 deg C, 2.) -4 deg C to room temperature; Yield given. Multistep reaction;
参考文献
Chedekel, Miles R.; Sharp, Dale E.; Jeffery, Gary A.
Synthetic Communications, 1980 , vol. 10, # 3 p. 167 - 174
