1-吗啉基-1-环己烯合成路线 （共 150 条）
反应条件
1: With N-ethyl-N,N-diisopropylamine in acetonitrile
T=60°C; 1 h; Sealed tubeMicrowave irradiation;
2: With water; citric acid in acetonitrile
参考文献
Pazdzierniok-Holewa, Agnieszka; Adamek, Jakub; Mazurkiewicz, Roman; Zielinska, Katarzyna
Phosphorus, Sulfur and Silicon and the Related Elements, 2013 , vol. 188, # 1-3 p. 205 - 212
反应条件
methanol; ammonia
T=70°C; 3 h;
参考文献
Tohda; Eiraku; Nakagawa; Usami; Ariga; Kawashima; Tani; Watanabe; Mori
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 10 p. 2820 - 2827
反应条件
ammonia in acetonitrile
T=100°C; 3 h;
参考文献
Nishiwaki, Nagatoshi; Matsunaga, Tomoko; Thoda, Yasuo; Ariga, Masahiro
Heterocycles, 1994 , vol. 38, # 2 p. 249 - 252
反应条件
hydrogenchloride; triethylamine
1.) CHCl3, RT, overnight, 2.) CHCl3, reflux, 5 h; Multistep reaction;
参考文献
Fos, Empar; Borras, Liset; Gasull, Maria; Mauleon, David; Carganico Germano
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 1 p. 203 - 208
反应条件
1: 50 percent / dimethylformamide
2: 86 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 5 h / Heating
3: 80 percent / t-BuOK / methanol / 1 h / 0 °C
4: 93 percent / sodium hydroxide / methanol; H2O / 0.17 h / Heating
View Scheme
参考文献
Haroun; Helissey; Giorgi-Renault
Synthetic Communications, 2001 , vol. 31, # 15 p. 2329 - 2334
反应条件
1: 50 percent / toluene / 3 h / 60 - 70 °C
2: 60 percent / conc. HCl / 0.5 h / 105 °C
3: 73.4 percent / saturated aq. Ba(OH)2 / methanol / 0.5 h / Heating
4: 80 percent / ethanol / 0.5 h / Heating
View Scheme
参考文献
Takeuchi, Naoki; Nakagawa, Hideo; Kamisato, Masahiro; Tobinaga, Seisho
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 8 p. 2460 - 2467
反应条件
in tetrachloromethane
T=60°C; 2 h; var.: time;
参考文献
Takeuchi, Naoki; Nakagawa, Hideo; Kamisato, Masahiro; Tobinaga, Seisho
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 8 p. 2460 - 2467
反应条件
(i), (ii) aq. HCl; Multistep reaction;
参考文献
Risaliti,A. et al.
Tetrahedron, 1967 , vol. 23, p. 1451 - 1459
反应条件
1: triethylamine / CHCl3 / 3 h / 45 °C
2: 21.2 g / HCl / CHCl3 / 5 h / Heating
3: 97 percent / hydrazine hydrate / methanol / 0.5 h / 30 °C
4: 82 percent / Pd/C / various solvent(s) / 24 h / Heating
View Scheme
参考文献
Huang, Li-Jiau; Shih, Mei-Ling; Chen, Hua-Sin; Pan, Shiow-Lin; Teng, Che-Ming; Lee, Fang-Yu; Kuo, Sheng-Chu
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 2 p. 528 - 536
反应条件
1: in toluene
T=20°C; 3 h;
2: With dodecacarbonyltriiron; trifluoroacetic acid in toluene
3 h; Reflux;
参考文献
Shionogi and Co., Ltd.
Patent: EP2460794 A1, 2012 ;
Location in patent: Page/Page column 79-80 ;
