1-吗啉基-1-环己烯合成路线 （共 150 条）
反应条件
1: 86 percent / toluene / 3 h / Ambient temperature
2: 55 percent / Fe3(CO)12, trifluoroacetic acid / 1,2-dichloro-ethane / 3 h / 80 °C
View Scheme
参考文献
Nakanishi, Saburo; Shirai, Yoshihiro; Takahashi, Kenji; Otsuji, Yoshio
Chemistry Letters, 1981 , p. 869 - 872
反应条件
(i) Et3N, CHCl3, (ii) aq. HCl, (iii) aq. KOH; Multistep reaction;
参考文献
Denny,W.A.; Cain,B.F.
Journal of Medicinal Chemistry, 1978 , vol. 21, p. 430 - 437
反应条件
potassium hydroxide
1.) xylene, reflux, 10 h, 2.) H2O, EtOH, reflux, 2 h; Yield given. Multistep reaction;
参考文献
Terada, Atsusuke; Naruto, Shunji; Wachi, Kazuyuki; Tanaka, Shigeru; Iizuka, Yoshio; Misaka, Eiichi
Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 212 - 216
反应条件
in chlorobenzene
20 h;
参考文献
Behringer, Hans; Meinetsberger, Eike
Liebigs Annalen der Chemie, 1981 , # 10 p. 1729 - 1750
反应条件
in chloroform
45 h; Heating;
参考文献
Charlton, James L.; Sayeed, Vilayat A.; Lypka, Gerald N.
Canadian Journal of Chemistry, 1982 , vol. 60, p. 1996 - 2001
反应条件
1: 3 percent / CHCl3 / 45 h / Heating
2: potassium carbonate / acetone / 18 h / Heating
View Scheme
参考文献
Charlton, James L.; Sayeed, Vilayat A.; Lypka, Gerald N.
Canadian Journal of Chemistry, 1982 , vol. 60, p. 1996 - 2001
参考文献
Sharanin, Yu. A.; Rodinovskaya, L. A.; Litvinov, V. P.; Promonenkov, V. K.; Mortikov, V. Yu.; Shestopalov, A. M.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 3 p. 619 - 620
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 3 p. 683 - 684
反应条件
hydrogenchloride; triethylamine
1.) acetonitrile, 14 h, reflux, 2.) 1 h, room temperature; Yield given. Multistep reaction;
参考文献
Scholz, Dieter
Monatshefte fuer Chemie, 1984 , vol. 115, p. 655 - 658
反应条件
in diethyl ether
8 h; Heating;
参考文献
Ekcstein, Zygmunt; Rusek, Dorota; Bany, Robert; Jelenski, Pawel
Polish Journal of Chemistry, 1981 , vol. 55, # 6 p. 1253 - 1264
反应条件
hydrogenchloride; potassium hydroxide; triethylamine
Yield given. Multistep reaction;
参考文献
Klotz, Philippe; Slaoui-Hasnaoui, Amal; Baneres, Jean-Louis; Duckert, Jean-Frederic; Rossi, Jean-Claude; Kerbal, Abdelali
Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2278 - 2288
