3-羟基-4-甲氧基苯甲酸甲酯合成路线 （共 35 条）
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6384080 B1, 2002 ;
参考文献
Lovecy; Robinson; Sugasawa
Journal of the Chemical Society, 1930 , p. 817,818
反应条件
1: 95 percent / K2CO3 / dimethylformamide / 4 h / 70 °C
2: 89 percent / nitric acid; acetic acid; acetic anhydride / 6 h / 20 °C
3: 77 percent / Fe; acetic acid / methanol / 0.5 h / 50 - 60 °C
View Scheme
参考文献
Li, Ri-Dong; Zhang, Xin; Li, Qiao-Yan; Ge, Ze-Mei; Li, Run-Tao
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 12 p. 3637 - 3640
反应条件
1.1: 77 percent / tricaprylmethylammonium chloride / acetone / Heating
2.1: 79 percent / nitric acid; AcOH / 2 h / Heating
3.1: 93 percent / Fe; aq. NH4Cl / methanol / 4 h / Heating
4.1: 8 h / Heating
5.1: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C
5.2: 47 percent / AcOH / tetrahydrofuran / -78 - 20 °C
View Scheme
参考文献
Boschelli; Ye; Wang; Dutia; Johnson; Wu; Miller; Powell; Yaczko; Young; Tischler; Arndt; Discafani; Etienne; Gibbons; Grod; Lucas; Weber
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3965 - 3977
反应条件
1.1: tetrabutyl-ammonium chloride; potassium carbonate / water; toluene / 2 h / 80 °C
1.2: 2 h / |Reflux
2.1: thionyl chloride; 1-methyl-pyrrolidin-2-one / toluene / 3 h / 20 °C
View Scheme
参考文献
OTSUKA PHARMACEUTICAL CO., LTD.; OKADA, Minoru; KABUKI, Takashi; FUJIEDA, Shigeo; KOSEKI, Nao
Patent: WO2014/34958 A1, 2014 ;
