4-氯-5-碘-2-氨基吡啶合成路线 （共 3 条）
反应条件
1: tetrakis(triphenylphosphine) palladium(0) / 1-methyl-pyrrolidin-2-one / 2 h / 135 °C / |Inert atmosphere 2: water; sulfuric acid / 18 h / 100 °C View Scheme
参考文献
BIOTA EUROPE LTD; TYNDALL, Edward Malcolm; CZAPLEWSKI, Lloyd George; FISHWICK, Colin William Gordon; YULE, Ian Andrew; MITCHELL, Jeffrey Peter; ANDERSON, Kelly Helen; PITT, Gary Robert William
Patent: WO2013/91011 A1, 2013 ;
反应条件
1: trifluoroacetic acid; tert.-butylnitrite / 17 h / 3 - 20 °C 2: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 1 h / 120 °C View Scheme
参考文献
Genentech, Inc.
Patent: US2012/245144 A1, 2012 ;
反应条件
N-iodo-succinimide in N,N-dimethyl-formamide
T=20°C; 18 h;
参考文献
Genentech, Inc.
Patent: US2012/245144 A1, 2012 ;
Location in patent: Page/Page column 125-126 ;
