3',4'-二甲氧基-2-甲基苯丁酮合成路线 （共 5 条）
反应条件
N,N,N',N,-tetramethylethylenediamine; methyl iodide in tetrahydrofuran; hexane; cyclohexane
T=-30 - 20°C;
参考文献
Chau, Nguyet Trang Thanh; Nguyen, Thi Huu; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Tetrahedron, 2008 , vol. 64, # 46 p. 10552 - 10557
反应条件
aluminium trichloride in benzene
参考文献
Moffett,R.B. et al.
Journal of Medicinal Chemistry, 1964 , vol. 7, p. 178 - 186
反应条件
PPA
T=60°C; Friedel-Crafts acylation; 15 h;
参考文献
Kraft, Philip; Eichenberger, Walter
European Journal of Organic Chemistry, 2003 , # 19 p. 3735 - 3743
反应条件
1: sec.-butyllithium; 3,4-dimethoxy-benzoic acid With N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; hexane; cyclohexane
T=-78 - -30°C; 2 h;
2: methyl iodide in tetrahydrofuran; hexane; cyclohexane
T=-30 - 20°C; Further stages.;
参考文献
Chau, Nguyet Trang Thanh; Nguyen, Thi Huu; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Tetrahedron, 2008 , vol. 64, # 46 p. 10552 - 10557
反应条件
pyridine hydrochloride
T=200 - 220°C;
参考文献
Moffett,R.B. et al.
Journal of Medicinal Chemistry, 1964 , vol. 7, p. 178 - 186
