2-氨基-5-甲氧基苯甲酸合成路线 （共 68 条）
反应条件
1: With hydrogenchloride; water; sodium nitrite 2: With disodium disulfide
参考文献
Marks, Andrew R.; Landry, Donald W.; Deng, Shi Xian; Cheng, Zhen Zhuang
Patent: US2005/215540 A1, 2005 ;
Location in patent: Page/Page column 37 ;
反应条件
1.1: tetrahydrofuran / 70 °C 2.1: hydrogenchloride / ethanol / 70 °C 2.2: 5 °C View Scheme
参考文献
Koay, Natalie; Campeau, Louis-Charles
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 2 p. 473 - 478
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in acetonitrile T=20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2006/32470 A1, 2006 ;
Location in patent: Page/Page column 32 ;
反应条件
1.1: 97 percent / tetrahydrofuran / 18 h / 20 °C 2.1: Et3N / ethanol; H2O / 0.17 h / 20 °C 2.2: ethanol; H2O / 3 h / Heating View Scheme
参考文献
Acker, Timothy M.; Khatri, Alpa; Vance, Katie M.; Slabber, Cathryn; Bacsa, John; Snyder, James P.; Traynelis, Stephen F.; Liotta, Dennis C.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 16 p. 6434 - 6456
反应条件
1: borane-THF / tetrahydrofuran / 1.67 h / 0 - 30 °C / |Inert atmosphere 2: manganese(IV) oxide / dichloromethane / 23 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5810 - 5831
反应条件
1.1: 1 h / 200 °C 2.1: N,N-diethylaniline; trichlorophosphate / 6 h / Reflux 3.1: zinc; water; ammonia / dichloromethane / 2 h / Reflux 3.2: pH 7 View Scheme
参考文献
N30 PHARMACEUTICALS, LLC; SUN, Xicheng; QIU, Jian; STOUT, Adam
Patent: WO2012/83165 A1, 2012 ;
反应条件
thionyl chloride; sodium in methanol
参考文献
Zeneca Limited
Patent: US5457105 A1, 1995 ;
US 5457105 A
参考文献
Journal of the American Chemical Society, , vol. 68, p. 1599,1601
反应条件
1.1: 1,4-dioxane / 1 h / Cooling; Reflux 2.1: dimethyl sulfoxide / 2 h / 157 °C 3.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran; mineral oil / Inert atmosphere 3.2: Cooling; Inert atmosphere 3.3: 18 h / 20 °C / Inert atmosphere 4.1: boron tribromide / dichloromethane / -70 °C 4.2: 20 °C / Cooling View Scheme
参考文献
GE HEALTHCARE LIMITED; WOODCRAFT, John; JONES, Clare; GAETA, Alessandra; TRIGG, William; JONES, Paul; PLANT, Stuart
Patent: WO2011/42550 A1, 2011 ;
反应条件
thionyl chloride; LiAlH4; Na2S2; triethylamine in tetrahydrofuran
参考文献
Marks, Andrew Robert; Landry, Donald W.; Deng, Shi Xian; Cheng, Zhen Zhuang
Patent: US2004/229781 A1, 2004 ;
