2-氨基-5-甲氧基苯甲酸合成路线 （共 68 条）
反应条件
acetic acid 1.) reflux, 45 min, 2.) room temperature, 18 h;
参考文献
Boden, Neville; Bushby, Richard J.; Clark, Leslie D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 543 - 551
反应条件
1.1: 32 percent / hydrochloric acid / 12 h / 20 °C 2.1: 82 percent / pyridine / CH2Cl2 / 1 h / 20 °C 3.1: 91 percent / DIBAL / toluene / 1 h / -78 °C 4.1: 91 percent / MnO2 / benzene / 4 h / Heating 5.1: 97 percent / K2CO3 / dimethylformamide / 1 h / 80 °C 6.1: KN(TMS)2 / tetrahydrofuran / 0.25 h / -78 °C 6.2: 98 percent / tetrahydrofuran / 1 h / -78 - 20 °C 7.1: 95 percent / Cl2Ru(=CHPh)(PCy3)2 / CH2Cl2 / 1 h / 50 °C View Scheme
参考文献
Arisawa, Mitsuhiro; Theeraladanon, Chumpol; Nishida, Atsushi; Nakagawa, Masako
Tetrahedron Letters, 2001 , vol. 42, # 45 p. 8029 - 8033
反应条件
1: 1.5 h / 200 °C 2: 1.8 g / POCl3; N,N-dimethylaniline / 16 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 10 p. 2297 - 2300
反应条件
1.1: 2.25 h / Reflux 2.1: toluene; diethyl ether / 1 h / 0 - 20 °C 2.2: 2 h / Reflux 3.1: chloroform / 1.5 h / 60 °C 4.1: triethylamine / dichloromethane / 24 h / Reflux 5.1: acetic acid / 1,2-dichloro-ethane / 2 h / 60 °C 6.1: tetraphosphorus decasulfide; sodium carbonate / 1,2-dichloro-ethane / 2 h / 70 °C 7.1: hydrazine hydrate / tetrahydrofuran / 4 h / 0 - 15 °C 8.1: triethylamine / tetrahydrofuran / 1 h / 20 °C 9.1: acetic acid / tetrahydrofuran / 48 h / 20 °C 10.1: sodium hydroxide / tetrahydrofuran / 5 h / 20 °C 11.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 3 h / 20 °C 11.2: 48 h View Scheme
参考文献
Gosmini, Romain Luc Marie; Mirguet, Olivier
Patent: US2012/220573 A1, 2012 ;
反应条件
hydrogenchloride Heating / reflux;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2006/41773 A2, 2006 ;
Location in patent: Page/Page column 304 ;
WO 2006/041773 A2
反应条件
hydrogenchloride T=20°C; 12 h;
参考文献
Theeraladanon, Chumpol; Arisawa, Mitsuhiro; Nishida, Atsushi; Nakagawa, Masako
Tetrahedron, 2004 , vol. 60, # 13 p. 3017 - 3035
参考文献
Oeberg, Christopher T.; Strand, Marten; Andersson, Emma K.; Edlund, Karin; Tran, Nam Phuong Nguyen; Mei, Ya-Fang; Wadell, Goeran; Elofsson, Mikael
Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3170 - 3181
反应条件
sodium hydrogencarbonate in tetrahydrofuran; water T=20°C; 24 h;
参考文献
Journal of Medicinal Chemistry, , vol. 57, # 3 p. 793 - 816
参考文献
LeMahieu; Carson; Nason; Parrish; Welton; Baruth; Yaremko
Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 420 - 425
反应条件
Diazotization.Umsetzen mit Kupferbromuer-Loesung;
参考文献
Pschorr
Justus Liebigs Annalen der Chemie, 1912 , vol. 391, p. 44
