2-氨基-5-甲氧基苯甲酸合成路线 （共 68 条）
反应条件
1: With hydrogenchloride; sodium nitrite
T=5°C;
2: With sulfur; sodium sulfide; sodium hydroxide
T=5°C;
3: With acetic acid; zinc
48 h; Heating;
参考文献
Parhi, Ajit K.; Wang, Julie L.; Oya, Shunichi; Choi, Seok-Rye; Kung, Mei-Ping; Kung, Hank F.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 26 p. 6673 - 6684
反应条件
hydrogenchloride; sodium hydroxide; sodium nitrite
Multistep reaction;
参考文献
Hollis Showalter; Angelo; Berman; Kanter; Ortwine; Ross-Kesten; Sercel; Turner; Werbel; Worth; Elslager; Leopold; Shillis
Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1527 - 1539
反应条件
1.1: sodium nitrite; hydrogenchloride / water / 1 h / 0 °C
1.2: 0 - 90 °C
2.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 0 - 20 °C
3.1: pyridinium chlorochromate; silica gel / dichloromethane / 2 h / 0 - 20 °C
View Scheme
参考文献
Zhou, Ping-Xin; Luo, Jian-Yi; Zhao, Lian-Biao; Ye, Yu-Ying; Liang, Yong-Min
Chemical Communications, 2013 , vol. 49, # 31 p. 3254 - 3256
反应条件
potassium iodide in triglyme (triethylene glycol dimethyl ether)
参考文献
Hoffmann-La Roche Inc.
Patent: US4348396 A1, 1982 ;
反应条件
1: 16.7 percent / conc. HCl / ethanol / 24 h / Heating
2: 56.2 percent / p-toluenesulfonyl chloride, pyridine / dimethylformamide / 42 h / 100 °C
View Scheme
参考文献
Schwender, Charles F.; Sunday, Brooks R.; Decker, Victoria L.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 742 - 745
反应条件
HNO2; copper
Yield given. Multistep reaction;
参考文献
Insole, Joan M.
Journal of Chemical Research, Miniprint, 1990 , # 12 p. 2831 - 2867
反应条件
1: conc. H2SO4
2: pyridine / 20 h / Heating
View Scheme
参考文献
Archer; Miller; Rej; Periana; Fricker
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 220 - 227
反应条件
1: conc. H2SO4
2: pyridine / 20 h / Heating
3: 1.7 g / 48percent HI / 3 h / Heating
View Scheme
参考文献
Archer; Miller; Rej; Periana; Fricker
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 220 - 227
反应条件
1: conc. H2SO4
2: 650 mg / 48percent HI, acetic acid / 2 h / Heating
3: 200 mg / pyridine / 16 h / Heating
View Scheme
参考文献
Archer; Miller; Rej; Periana; Fricker
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 220 - 227
反应条件
1: conc. H2SO4
2: pyridine / 20 h / Heating
View Scheme
参考文献
Archer; Miller; Rej; Periana; Fricker
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 220 - 227
