2-氨基-5-甲氧基苯甲酸合成路线 （共 68 条）
反应条件
1: conc. H2SO4
2: pyridine / 20 h / Heating
3: 48percent HI / 20 h / Heating
View Scheme
参考文献
Archer; Miller; Rej; Periana; Fricker
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 220 - 227
反应条件
1: conc. H2SO4
2: pyridine / 20 h / Heating
3: 48percent HI / 20 h / Heating
View Scheme
参考文献
Archer; Miller; Rej; Periana; Fricker
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 220 - 227
反应条件
1.1: tetrahydrofuran / 2 h / 70 °C
2.1: triethylamine / ethanol / 0.17 h
2.2: 2 h / |Reflux
3.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / |Inert atmosphere
View Scheme
参考文献
Acker, Timothy M.; Khatri, Alpa; Vance, Katie M.; Slabber, Cathryn; Bacsa, John; Snyder, James P.; Traynelis, Stephen F.; Liotta, Dennis C.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 16 p. 6434 - 6456
反应条件
1: With sodium carbonate in water
T=20°C; 2 h;
2: With hydrogenchloride in water
参考文献
Icagen, Inc.
Patent: US2005/267032 A1, 2005 ;
Location in patent: Page/Page column 21, 22 ;
反应条件
hydrogenchloride
24 h; Heating;
参考文献
Wieking, Karen; Knockaert, Marie; Leost, Maryse; Zaharevitz, Daniel W.; Meijer, Laurent; Kunick, Conrad
Archiv der Pharmazie, 2002 , vol. 335, # 7 p. 311 - 317
反应条件
1: 54 percent / Na2CO3 / H2O / RT, 1 h, 40/50 deg C, 8 h
2: 78 percent / Et3N / 3 h / 130 °C
3: 85 percent / NaCl / dimethylsulfoxide / 2 h / 155 - 160 °C
View Scheme
参考文献
Kawada; Kawano; Sugihara; et al.
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 7 p. 1900 - 1911
参考文献
Morrison; Mulholland
Journal of the Chemical Society, 1958 , p. 2702,2703
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
参考文献
Jia, Min-Qiang; You, Shu-Li
ACS Catalysis, 2013 , vol. 3, # 4 p. 622 - 624
