7-氧杂二环[4.1.0]庚烷-2-酮合成路线 （共 57 条）
反应条件
1: methanol; H2O
2: acetophenone (sensitizer) / benzene / Irradiation; other solvent, reaction time, without sensitizer; sensibility of irradiation
View Scheme
参考文献
Arnould, J.C.; Cossy, J.; Pete, J.P.
Tetrahedron, 1980 , vol. 36, p. 1585 - 1592
反应条件
sodium acetate; palladium diacetate; ethylene glycol; poly(ethylene glycol) in water; acetonitrile
T=150°C; 0.333333 h; microwave irradiation;
参考文献
Svennebring, Andreas; Garg, Neeraj; Nilsson, Peter; Hallberg, Anders; Larhed, Mats
Journal of Organic Chemistry, 2005 , vol. 70, # 12 p. 4720 - 4725
反应条件
palladium diacetate; ethylene glycol; N-ethyl-N,N-diisopropylamine; poly(ethylene glycol) in water; acetonitrile
T=150°C; 0.333333 h; microwave irradiation;
参考文献
Svennebring, Andreas; Garg, Neeraj; Nilsson, Peter; Hallberg, Anders; Larhed, Mats
Journal of Organic Chemistry, 2005 , vol. 70, # 12 p. 4720 - 4725
反应条件
1: iPr2NEt / acetonitrile / 3 h / 100 °C
2: sodium acetate; palladium acetate; poly(ethylene glycol) / acetonitrile; H2O / 0.33 h / 150 °C / microwave irradiation
View Scheme
参考文献
Svennebring, Andreas; Garg, Neeraj; Nilsson, Peter; Hallberg, Anders; Larhed, Mats
Journal of Organic Chemistry, 2005 , vol. 70, # 12 p. 4720 - 4725
反应条件
sodium acetate; palladium diacetate; ethylene glycol; poly(ethylene glycol) in water; acetonitrile
T=150°C; 0.333333 h; microwave irradiation;
参考文献
Svennebring, Andreas; Garg, Neeraj; Nilsson, Peter; Hallberg, Anders; Larhed, Mats
Journal of Organic Chemistry, 2005 , vol. 70, # 12 p. 4720 - 4725
反应条件
sodium acetate; palladium diacetate; ethylene glycol; poly(ethylene glycol) in water; acetonitrile
T=180°C; 0.333333 h; microwave irradiation;
参考文献
Svennebring, Andreas; Garg, Neeraj; Nilsson, Peter; Hallberg, Anders; Larhed, Mats
Journal of Organic Chemistry, 2005 , vol. 70, # 12 p. 4720 - 4725
反应条件
1: LDA / tetrahydrofuran / 1 h / -78 deg C -> 0 deg C
2: 2.) TsOH / 1.) THF, -23 deg C, 2 h, 2.) PhH, reflux, 15 min
View Scheme
参考文献
Wender, Paul A.; Erhardt, Jeanette M.; Letendre, Leo J.
Journal of the American Chemical Society, 1981 , vol. 103, # 8 p. 2114 - 2116
反应条件
toluene-4-sulfonic acid; lithium diisopropyl amide
1.) THF, -23 deg C, 2 h, 2.) PhH, reflux, 15 min; Yield given. Multistep reaction;
参考文献
Wender, Paul A.; Erhardt, Jeanette M.; Letendre, Leo J.
Journal of the American Chemical Society, 1981 , vol. 103, # 8 p. 2114 - 2116
反应条件
Bu3Sn(tripiperidinophosphine oxide)I; tri-n-butyl-tin hydride in tetrahydrofuran
22 h; Ambient temperature;
参考文献
Kawakami, Takayo; Tanizawa, Daisuke; Shibata, Ikuya; Baba, Akio
Tetrahedron Letters, 1995 , vol. 36, # 51 p. 9357 - 9360
反应条件
1: 96 percent / NaOH / H2O / 0.5 h / 30 °C / pH 9.0
2: 85 percent / sodium periodate / H2O / 3 h / 30 °C
View Scheme
参考文献
Fringuelli, Francesco; Pizzo, Ferdinando; Vaccaro, Luigi
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2315 - 2321
