7-氧杂二环[4.1.0]庚烷-2-酮合成路线 （共 57 条）
反应条件
aminopropylated Silica-Gel hydrochloride (APSG*HCl) resin
24 h; Ambient temperature;
参考文献
Gasparrini, F.; Giovannoli, M.; Misiti, D.; Palmieri, G.
Tetrahedron, 1984 , vol. 40, # 9 p. 1491 - 1500
反应条件
sulfuric acid
T=20°C; 2 h; Title compound not separated from byproducts;
参考文献
Habermehl, Gerhard G.; Wippermann, Irene
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1991 , vol. 46, # 10 p. 1421 - 1424
反应条件
sulfuric acid
T=20°C; 0.1 h;
参考文献
Habermehl, Gerhard G.; Wippermann, Irene
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1991 , vol. 46, # 10 p. 1421 - 1424
反应条件
1: 7-oxabicyclo[4.1.0]heptan-2-one With lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: phenyllithium in tetrahydrofuran; hexane
T=-23°C; 2 h;
3: With toluene-4-sulfonic acid in toluene
2 h; Heating; Further stages.;
参考文献
Tang, Zilong; Mathieu, Benoit; Tinant, Bernard; Dive, Georges; Ghosez, Leon
Tetrahedron, 2007 , vol. 63, # 35 p. 8449 - 8462
反应条件
toluene-4-sulfonic acid; lithium diisopropyl amide
1.) THF, -23 deg C, 2 h, 2.) PhH, reflux, 15 min; Yield given. Multistep reaction;
参考文献
Wender, Paul A.; Erhardt, Jeanette M.; Letendre, Leo J.
Journal of the American Chemical Society, 1981 , vol. 103, # 8 p. 2114 - 2116
反应条件
boron trifluoride diethyl etherate; tetraethylammonium bromide in dichloromethane
T=25°C; 0.0833333 h;
参考文献
Mandal, Arun K.; Mahajan, S. W.
Tetrahedron, 1988 , vol. 44, # 8 p. 2293 - 2300
反应条件
1: diethyl ether; tetrahydrofuran / 0.25 h / -78 °C
2: 55 percent / n-BuLi / hexane; tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Doris, Eric; Dechoux, Luc; Mioskowski, Charles
Journal of the American Chemical Society, 1995 , vol. 117, # 51 p. 12700 - 12704
