formic acid; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in water; acetone; toluene T=100°C; 0.333333 h; microwave irradiation;

1: 4-methoxy-benzaldehyde; acetophenone With sodium hydroxide T=25°C; 2.5 h; 2: benzonitrile With hydroxylamine; acetic acid T=25°C; 2.5 h; 3: T=150°C; 0.05 h; microwave irradiation; Further stages.;

1: 71 percent / NaH / tetrahydrofuran / 1 h / 0 - 25 °C 2: 63 percent / Li2CO3 / N,N-dimethyl-acetamide / 24 h / 95 °C 3: 83 percent / HCO2H; K2CO3 / Pd(dppf)Cl2 / toluene; acetone; H2O / 0.33 h / 100 °C / microwave irradiation View Scheme

1: 63 percent / Li2CO3 / N,N-dimethyl-acetamide / 24 h / 95 °C 2: 83 percent / HCO2H; K2CO3 / Pd(dppf)Cl2 / toluene; acetone; H2O / 0.33 h / 100 °C / microwave irradiation View Scheme