反应条件
1: 1) nBuLi / 1) THF, hexane, a) 0 deg C, 1 h, b) rt, 3 h, 2a) 0 deg C, 1 h, b) rt, overnight
2: 43 percent / AlCl3 / CH2Cl2 / 1) 0 deg C, 1 h, 2) rt, 0.5 h
3: 90 percent / BBr3 / CH2Cl2 / 1) -50 deg C, 1 h, 2) rt, 2 h
View Scheme
参考文献
Brown; Bersntein; Cronk; Dossett; Hebbel; Maduskuie Jr.; Shapiro; Vacek; Yee; Willard; Krell; Snyder
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 807 - 826
