4-甲基-2H-吡喃-2,6(3h)-二酮合成路线 （共 25 条）
反应条件
1: 83 percent / diethyl ether / 1 h / Ambient temperature 2: 2.) Ag2O, MgSO4 / 1.) xylene, reflux, 5 d, 2.) xylene, RT, 12 h 3: 100 percent / 48percent HBr / acetic acid / 5 h / Heating 4: 1.) boric acid, 65percent oleum, 2.) KOH, 3.) 6N HCl View Scheme
参考文献
Ahmed, Salman A.; Bardshiri, Esfandiar; Simpson, Thomas J.
Journal of the Chemical Society, Chemical Communications, 1987 , p. 883 - 884
反应条件
1: 80 percent / diethyl ether / 12 h / 25 °C 2: 2.) Ag2O, MgSO4 / 1.) xylene, reflux, 5 d; 2.) RT, 12 h 3: 100 percent / HBr / acetic acid / 5 h / Heating View Scheme
参考文献
Ahmed, Salman A.; Bardshiri, Esfandiar; Simpson, Thomas J.
Journal of the Chemical Society, Chemical Communications, 1987 , p. 883 - 884
反应条件
1: 80 percent / diethyl ether / 12 h / 25 °C 2: 2.) Ag2O, MgSO4 / 1.) xylene, reflux, 5 d; 2.) RT, 12 h 3: 100 percent / HBr / acetic acid / 5 h / Heating 4: 100 percent / cc H2SO4 / 0.5 h / Ambient temperature View Scheme
参考文献
Jung; Lowe III; Lyster; et al.
Tetrahedron, 1984 , vol. 40, # 22 p. 4751 - 4766
反应条件
acetic anhydride
T=70°C; 0.5 h;
参考文献
Jung; Lowe III; Lyster; et al.
Tetrahedron, 1984 , vol. 40, # 22 p. 4751 - 4766
反应条件
in xylene
20 h; Heating;
参考文献
Ahmed, Salman A.; Bardshiri, Esfandiar; McIntyre, C. Rupert; Simpson, Thomas J.
Australian Journal of Chemistry, 1992 , vol. 45, # 1 p. 249 - 274
反应条件
acetic anhydride
1.5 h; Heating;
参考文献
Lewer, Paul; MacMillan, Jake
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 7 p. 1417 - 1420
反应条件
acetyl chloride
T=52°C; 16 h; Inert atmosphere;
参考文献
Manoni, Francesco; Connon, Stephen J.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 10 p. 2628 - 2632
Angew. Chem., 2014 , vol. 126, # 10 p. 2666 - 2670,5
反应条件
1: aqueous alkali
2: acetic acid anhydride; benzene
3: 100 °C
View Scheme
参考文献
Adams; Van Duuren
Journal of the American Chemical Society, 1953 , vol. 75, p. 2377
反应条件
1: 1.) O3, HOAc; 2.) H2O2, HOAc / 1.) CH2Cl2
2: Heating
3: xylene / Heating
View Scheme
参考文献
Ahmed, Salman A.; Bardshiri, Esfandiar; Simpson, Thomas J.
Journal of the Chemical Society, Chemical Communications, 1987 , p. 883 - 884
反应条件
1: 95 percent / NaOH / H2O / 1 h / 70 °C
2: 85 percent / Ac2O / 0.5 h / 70 °C
View Scheme
参考文献
Jung; Lowe III; Lyster; et al.
Tetrahedron, 1984 , vol. 40, # 22 p. 4751 - 4766
