4-甲基-2H-吡喃-2,6(3h)-二酮合成路线 （共 25 条）
反应条件
1: NaOH / H2O / 7 h / Heating
2: acetic anhydride / 12 h / 45 - 50 °C
View Scheme
参考文献
Cornforth, John; Hawes, John E.; Mallaby, Richard
Australian Journal of Chemistry, 1992 , vol. 45, # 1 p. 179 - 185
反应条件
acetic anhydride
T=45 - 50°C; 12 h;
参考文献
Cornforth, John; Hawes, John E.; Mallaby, Richard
Australian Journal of Chemistry, 1992 , vol. 45, # 1 p. 179 - 185
反应条件
1.1: acetonitrile / 6 h / 82 °C
1.2: 1 h / 0 - 20 °C
2.1: toluene-4-sulfonic acid / toluene / 5 h / 111 °C / |Dean-Stark
2.2: 18 h / 66 °C
3.1: potassium hydroxide / water; ethanol / 3 h / 78 °C
3.2: 20 °C / pH 3
4.1: acetyl chloride / 16 h / 52 °C / |Inert atmosphere
View Scheme
参考文献
Manoni, Francesco; Connon, Stephen J.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 10 p. 2628 - 2632
Angew. Chem., 2014 , vol. 126, # 10 p. 2666 - 2670,5
反应条件
1.1: potassium hydroxide / water; ethanol / 3 h / 78 °C
1.2: 20 °C / pH 3
2.1: acetyl chloride / 16 h / 52 °C / |Inert atmosphere
View Scheme
参考文献
Manoni, Francesco; Connon, Stephen J.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 10 p. 2628 - 2632
Angew. Chem., 2014 , vol. 126, # 10 p. 2666 - 2670,5
反应条件
1.1: triethylamine; DMEG / dichloromethane / 0.5 h / 0 - 20 °C / |Inert atmosphere
2.1: acetonitrile / 6 h / 82 °C
2.2: 1 h / 0 - 20 °C
3.1: toluene-4-sulfonic acid / toluene / 5 h / 111 °C / |Dean-Stark
3.2: 18 h / 66 °C
4.1: potassium hydroxide / water; ethanol / 3 h / 78 °C
4.2: 20 °C / pH 3
5.1: acetyl chloride / 16 h / 52 °C / |Inert atmosphere
View Scheme
参考文献
Manoni, Francesco; Connon, Stephen J.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 10 p. 2628 - 2632
Angew. Chem., 2014 , vol. 126, # 10 p. 2666 - 2670,5
参考文献
Genvresse
Annales de Chimie (Cachan, France), 1891 , vol. <6> 24, p. 123
Full Text Show Details
Rogerson; Thorpe
Journal of the Chemical Society, 1905 , vol. 87, p. 1692
反应条件
1: 95 percent / LAH / tetrahydrofuran / 24 h / Ambient temperature
2: 31 percent / Jones reagent / acetone / 0 °C
View Scheme
参考文献
Nangia; Rao; Prasuna
Synthetic Communications, 1992 , vol. 22, # 4 p. 593 - 602
反应条件
pyridine
T=25°C; 1 h;
参考文献
Jung; Lowe III; Lyster; et al.
Tetrahedron, 1984 , vol. 40, # 22 p. 4751 - 4766
反应条件
2: 2.) Ag2O, MgSO4 / 1.) xylene, reflux
View Scheme
参考文献
Ahmed, Salman A.; Bardshiri, Esfandiar; McIntyre, C. Rupert; Simpson, Thomas J.
Australian Journal of Chemistry, 1992 , vol. 45, # 1 p. 249 - 274
反应条件
pyridine; diethyl ether
Erhitzen des Reaktionsprodukts bis auf 350grad;
参考文献
Wiley; Esterle
Journal of Organic Chemistry, 1957 , vol. 22, p. 1257
