4-甲基-2H-吡喃-2,6(3h)-二酮合成路线 （共 25 条）
反应条件
pyridine; diethyl ether
Erhitzen des Reaktionsprodukts auf 350grad;
参考文献
Wiley; Esterle
Journal of Organic Chemistry, 1957 , vol. 22, p. 1257
参考文献
Stern; del Campillo
Journal of Biological Chemistry, 1956 , vol. 218, p. 985,1000
Full Text Show Details
Hilz et al.
Biochemische Zeitschrift, 1958 , vol. 329, p. 476,484
参考文献
Wiley; Jarboe
Journal of the American Chemical Society, 1955 , vol. 77, p. 403
反应条件
1: 80 percent / diethyl ether / 12 h / 25 °C
2: 2.) Ag2O, MgSO4 / 1.) xylene, reflux, 5 d; 2.) RT, 12 h
3: 100 percent / HBr / acetic acid / 5 h / Heating
4: 100 percent / cc H2SO4 / 0.5 h / Ambient temperature
5: NaOH / H2O / 1.75 h / 100 °C
View Scheme
参考文献
Jung; Lowe III; Lyster; et al.
Tetrahedron, 1984 , vol. 40, # 22 p. 4751 - 4766
反应条件
1: 80 percent / diethyl ether / 12 h / 25 °C
2: 2.) Ag2O, MgSO4 / 1.) mesytilene, reflux, 74 h; 2.) RT, 12 h
3: 87 percent / HBr / acetic acid / 4 h / Heating
View Scheme
参考文献
Jung; Lowe III; Lyster; et al.
Tetrahedron, 1984 , vol. 40, # 22 p. 4751 - 4766
