4-苄基-1-(Boc-氨基乙酰基)-哌嗪合成路线 （共 3 条）
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 6 h; Inert atmosphere;
参考文献
Lee, Kyungae; Ren, Tao; Coite, Marceline; Gholamreza, Berahman; Misasi, John; Bruchez, Anna; Cunningham, James
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 2 p. 239 - 243
反应条件
1: BOC-glycine With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide in dichloromethane
T=0 - 20°C; 21 h;
2: 1-benzyl-piperazine in dichloromethane
T=20°C; 24 h;
参考文献
Scapecchi, Serena; Martini, Elisabetta; Manetti, Dina; Ghelardini, Carla; Martelli, Cecilia; Dei, Silvia; Galeotti, Nicoletta; Guandalini, Luca; Romanelli, Maria Novella; Teodori, Elisabetta
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 1 p. 71 - 85
反应条件
ammonium formate; palladium on activated charcoal in methanol
8 h; Heating;
参考文献
Scapecchi, Serena; Martini, Elisabetta; Manetti, Dina; Ghelardini, Carla; Martelli, Cecilia; Dei, Silvia; Galeotti, Nicoletta; Guandalini, Luca; Romanelli, Maria Novella; Teodori, Elisabetta
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 1 p. 71 - 85
