1,2,3,4-四氢异喹啉-3-羧酸合成路线 （共 42 条）
反应条件
Rh/Al2O3; ethanol T=50 - 100°C; P=11032.6 Torr; Hydrogenation;
参考文献
Rapala et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 3770
参考文献
Sanchez, Remedios; Luna, Hector; Perez, Herminia I.; Manjarrez, Norberto; Solis, Aida
Tetrahedron Asymmetry, 2001 , vol. 12, # 10 p. 1399 - 1401
反应条件
1: H2SO4 2: Pd/C / xylene / Heating 3: 98 percent / methanolic NH3 / Ambient temperature 4: 92 percent / triethylamine, trifluoroacetic anhydride / CH2Cl2 / 0.03 h / 0 °C View Scheme
参考文献
Langry, Kevin C.
Organic Preparations and Procedures International, 1994 , vol. 26, # 4 p. 429 - 438
反应条件
1: SOCl2 / 3 h 2: S / xylene / 48 h / Heating View Scheme
参考文献
Cain; Weber; Guzman; Cook; Barker; Rice; Crawley; Paul; Skolnick
Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1081 - 1091
反应条件
sodium hydroxide; boron trifluoride in tetrahydrofuran; methanol
参考文献
Astra AB
Patent: US6034097 A1, 2000 ;
US 6034097 A
参考文献
Chaniyara, Ravi; Kapuriya, Naval; Dong, Huajin; Lee, Pei-Chih; Suman, Sharda; Marvania, Bhavin; Chou, Ting-Chao; Lee, Te-Chang; Kakadiya, Rajesh; Shah, Anamik; Su, Tsann-Long
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 1 p. 275 - 286
反应条件
diethyl ether
und Erhitzen der bei 115grad/0.005 Torr siedenden Anteile des Reaktionsprodukts mit Palladium auf 160-170grad/20 Torr;
参考文献
Julian et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 180,182
反应条件
1: H2SO4
2: Pd/C / xylene / Heating
3: 98 percent / methanolic NH3 / Ambient temperature
View Scheme
参考文献
Langry, Kevin C.
Organic Preparations and Procedures International, 1994 , vol. 26, # 4 p. 429 - 438
反应条件
1: With cyanic acid sodium salt in N,N-dimethyl-formamide
T=70°C; 2 h;
2: With hydrogenchloride in water; N,N-dimethyl-formamide
T=70°C; pH=1; 2 h;
参考文献
Toussaint; Debreu-Fontaine; Maurice; Melnyk
Medicinal Chemistry, 2010 , vol. 6, # 6 p. 355 - 373
反应条件
sodium hydroxide; boron trifluoride in tetrahydrofuran; methanol
参考文献
Astra AB
Patent: US6034097 A1, 2000 ;
US 6034097 A
