1,4-diaza-bicyclo[2.2.2]octane in toluene Inert atmosphere;

暂无反应条件数据

1: PPTS / CH2Cl2 / Ambient temperature 2: 1) bipyridyl, n-BuLi / 1) THF, hexane, -78 deg C, 1h, 2) HMPA, RT, 24h 3: 1) disiamylborane, 2) HOAc / 1) THF, 0 deg C, 1h, 2) RT, 4h 4: 71 percent / 3N HCl / methanol / 1.5 h / Ambient temperature 5: 88 percent / pyridine / acetonitrile / 1 h / 0 °C 6: 43 percent / t-BuOOH, D-(-)-DIPT, Ti(O-i-Pr)4, molecular sieves 4 Angstroem / CH2Cl2 / 16 h / -21 °C 7: t-BuOOH, Ti(O-i-Pr)4, L-(+)-DIPT, molecular sieves 4 Angstroem / CH2Cl2 / -21 °C 8: PPh3, diethyl azodicarboxylate / tetrahydrofuran / 1 h / 0 °C 9: 1N NaOH / methanol / 1 h / 0 °C 10: 1) Bu3SnLi, 2) I2 / 1) THF, 0 deg C, 3h, 2) Et2O, 0 deg C 11: imidazole / dimethylformamide / Ambient temperature 12: 1) disiamylborane, 2) LiOH / 2) Pd(PPh3)4 / 1) THF, 0 deg C, 1h, 2) 40 degC, 12h 13: 79 percent / n-Bu4NF / tetrahydrofuran / 18 h / Ambient temperature View Scheme

1: PCC 2: 1) NaH View Scheme