2,4-二氟-5-硝基苯腈合成路线 (共 5 条)
反应条件
sulfuric acid; potassium nitrate in water T=0°C; 4 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/87530 A1, 2006 ;
Location in patent: Page/Page column 59 ;
WO 2006/087530 A1
反应条件
sulfuric acid; potassium nitrate
反应条件
1: NH3 2: H2 / Pd/C / 760 Torr View Scheme
参考文献
ADAMS, Christopher Michael; BABU, Charles; CAPPARELLI, Michael Paul; DING, Jian; EHARA, Takeru; JENDZA, Keith; JI, Nan; KARKI, Rajeshri Ganesh; KAWANAMI, Toshio; LIANG, Xue; MAINOLFI, Nello; POWERS, James J.; SERRANO-WU, Michael H.; ZHANG, Chun
Patent: US2013/296377 A1, 2013 ;
Location in patent: Paragraph 1122 ;
反应条件
ammonia in ethanol T=20°C;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; CIANCI, Christopher, W.; GERRITZ, Samuel; LI, Guo; PEARCE, Bradley, C.; PENDRI, Annapurna; SHI, Shuhao; ZHAI, Weixu; ZHU, Shirong
Patent: WO2012/33736 A1, 2012 ;
Location in patent: Page/Page column 60 ;
参考文献
Axys Pharmaceuticals, Inc.
Patent: US6150379 A1, 2000 ;