2-甲基-4-三氟甲基苯胺合成路线 （共 7 条）
反应条件
hydrogen; nickel in ethanol T=20°C; P=2844.39 Torr; 48 h;
参考文献
PHARMACOPEIA, INC.
Patent: WO2008/11392 A2, 2008 ;
Location in patent: Page/Page column 39-40 ;
WO 2008/011392 A2
反应条件
1: With trifluoroacetic acid in dichloromethane T=20°C; 0.5 h; 2: With sodium hydrogencarbonate in water; pentane
参考文献
Bristol-Myers Squibb Company
Patent: US2009/18132 A1, 2009 ;
Location in patent: Page/Page column 46 ;
US 20090018132 A1
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=100°C; 48 h;
参考文献
WO2007/79186 A2, ;
Page/Page column 98; 99 ;
反应条件
2-picoline; Na2S2O5; sulfur dioxide; zinc in N,N-dimethyl-formamide T=20°C; P=2250.2 - 3750.3 Torr; 2 h;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 8 p. 2293 - 2299
反应条件
1: With hydrogen fluoride; SbF5 T=-20 - 0°C; 0.5 h; 2: With pyridine; hydrogen fluoride T=-78 - 0°C;
参考文献
Debarge, Sebastien; Violeau, Bruno; Bendaoud, Nohair; Jacquesy, Jean-Claude
Tetrahedron Letters, 2003 , vol. 44, # 9 p. 1747 - 1750
反应条件
sodium sulfide; nitric acid; ammonium chloride; sulfur 1.) 15 min, 2.) methanol, H2O, 75 deg C, 5 h; Multistep reaction. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 51, # 20 p. 3903 - 3904
反应条件
1: With sulfuric acid; sodium nitrite in ethanol; water
T=0°C; 1 h;
2: With sodium iodide in ethanol; water
T=0 - 20°C; 1.5 h;
参考文献
MERCK and CO., INC.
Patent: WO2007/79186 A2, 2007 ;
Location in patent: Page/Page column 99 ;
