3-甲基-4-硝基三氟甲苯合成路线 （共 5 条）
反应条件
[Pd(η3-1-Ph-allyl)(μ-Cl)]2; cyclohexyl BrettPhos; sodium lauryl sulfate; cesium fluoride in toluene T=110°C; 12 h; Inert atmosphere;
参考文献
Samant, Bhupesh S.; Kabalka, George W.
Chemical Communications, 2011 , vol. 47, # 25 p. 7236 - 7238
反应条件
potassium fluoride; cyclohexyl BrettPhos; [(allyl)PdCl]2 in 1,4-dioxane T=130°C;
参考文献
Cho, Eun Jin; Senecal, Todd D.; Kinzel, Tom; Zhang, Yong; Watson, Donald A.; Buchwald, Stephen L.
Science, 2010 , vol. 328, # 5986 p. 1679 - 1681
反应条件
nitric acid T=0 - 5°C; 0.25 h; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 51, # 20 p. 3903 - 3904
反应条件
1.1: N,N-dimethyl-formamide dimethyl acetal / N,N-dimethyl-formamide / 24 h / 100 °C 1.2: 18 h / 20 °C 2.1: sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 - 20 °C View Scheme
参考文献
McAllister, Laura A.; Bechle, Bruce M.; Dounay, Amy B.; Evrard, Edelweiss; Gan, Xinmin; Ghosh, Somraj; Kim, Ji-Young; Parikh, Vinod D.; Tuttle, Jamison B.; Verhoest, Patrick R.
Journal of Organic Chemistry, 2011 , vol. 76, # 9 p. 3484 - 3497
