2-羟基-5-甲氧基苯甲醛合成路线 （共 150 条）
反应条件
anhydrous diethylamine hydrochloride in toluene
48 h; Heating;
参考文献
Dauzonne, Daniel; Royer, Rene
Synthesis, 1983 , # 10 p. 836 - 837
反应条件
4-methyl-morpholine; titanium tetrachloride
Yield given. Multistep reaction;
参考文献
Murata, Chiyomi; Masuda, Toshinobu; Kamochi, Yasuko; Todoroki, Kenichiro; Yoshida, Hideyuki; Nohta, Hitoshi; Yamaguchi, Masatoshi; Takadate, Akira
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 7 p. 750 - 758
反应条件
1: potassium carbonate / dimethylformamide
2: acetic acide / Heating
3: 87 percent
View Scheme
参考文献
Maillard; Langlois; Vo Van; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 353 - 358
反应条件
1: potassium carbonate / dimethylformamide
2: acetic acide / Heating
3: 87 percent
4: trimethylbenzyl ammonium hydroxide
5: hydrogen / Raney nickel / ethanol
View Scheme
参考文献
Maillard; Langlois; Vo Van; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 353 - 358
反应条件
1: potassium carbonate / dimethylformamide
2: acetic acide / Heating
3: 87 percent
4: trimethylbenzyl ammonium hydroxide
5: hydrogen / Raney nickel / ethanol
6: 72 percent
View Scheme
参考文献
Maillard; Langlois; Vo Van; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 353 - 358
反应条件
1: potassium carbonate / dimethylformamide
2: acetic acide / Heating
3: 87 percent
4: trimethylbenzyl ammonium hydroxide
5: hydrogen / Raney nickel / ethanol
6: 72 percent
7: 96 percent / ethanol / 20 h / Heating
8: 84 percent / boron tribromide / CH2Cl2 / 12 h
View Scheme
参考文献
Maillard; Langlois; Vo Van; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 353 - 358
反应条件
1: 99.7 percent / NaBH4 / ethanol / 1 h / 20 °C
2: 84.1 percent / acetonitrile / 1 h / Heating
3: 32.9 percent / triethylamine / toluene / 2 h / Heating
4: 92.9 percent / SnCl2 / ethanol / 2 h / Heating
View Scheme
参考文献
Ono, Masahiro; Cheng, Yan; Kimura, Hiroyuki; Cui, Mengchao; Kagawa, Shinya; Nishii, Ryuichi; Saji, Hideo
Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 2971 - 2979
反应条件
1: 99.7 percent / NaBH4 / ethanol / 1 h / 20 °C
2: 84.1 percent / acetonitrile / 1 h / Heating
3: 32.9 percent / triethylamine / toluene / 2 h / Heating
4: 92.9 percent / SnCl2 / ethanol / 2 h / Heating
5: 10.5 percent / BBr3 / CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
Ono, Masahiro; Kawashima, Hidekazu; Nonaka, Akemi; Kawai, Tomoki; Haratake, Mamoru; Mori, Hiroshi; Kung, Mei-Ping; Kung, Hank F.; Saji, Hideo; Nakayama, Morio
Journal of Medicinal Chemistry, 2006 , vol. 49, # 9 p. 2725 - 2730
反应条件
1: 99.7 percent / NaBH4 / ethanol / 1 h / 20 °C
2: 84.1 percent / acetonitrile / 1 h / Heating
View Scheme
参考文献
Ferino, Giulio; Cadoni, Enzo; Matos, Maria Joao; Quezada, Elias; Uriarte, Eugenio; Santana, Lourdes; Vilar, Santiago; Tatonetti, Nicholas P.; Yanez, Matilde; Vina, Dolores; Picciau, Carmen; Serra, Silvia; Delogu, Giovanna
ChemMedChem, 2013 , vol. 8, # 6 p. 956 - 966
反应条件
in acetonitrile
2 h;
参考文献
Guillaumel; Royer; Le Corre; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 5 p. 431 - 436
